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PENETAPAN STANDAR NASIONAL DARI VAKSIN DPT: Penetapan Standar Nasional Vaksin Pertussis | Prijanto | Buletin Penelitian Kesehatan

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  • PENETAPAN STANDAR NASIONAL DARI VAKSIN DPT: Penetapan Standar Nasional Vaksin Pertussis

    Muljanti Prijanto

    Abstract


    To check the potency of DPT vaccine, standard preparations of the components, namely Adsorbed Diphtheria Toxoid, Pertussis Vaccine, and Adsorbed Tetanus Toxoid are necessary.

    Since WHO International Standard Preparations are distributed only in limited amounts, WHO has suggested that each member country shold develop a National Standard, which is to be matched with International Standard Preparations.

    An Indonesian National Standard of DPT vaccine (lot 1) has been prepared and lyophilized at the National Institute of Health in Tokyo.

    The potency of the National Standard of Pertussis Vaccine was determined by Active Mouse Protection Test (AMPT). After several experiments, the potency of the National Standard of Pertussis Vaccine has been decided of being 12 IU/ml.

    Using the same standard preparations, namely the National Standards, it is hoped that from a lot of DPT vaccine, similar results of potency could be achieved when determined by Government Vaccine Quality Control laboratory and the Manufacturer's laboratory.

    Keywords


    DPT Vaccine; Pertussis Vaccine

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    Buletin Penelitian Kesehatan (Bulletin of Health Research, ISSN: 0125-9695. EISSN: 2338-3453) diterbitkan oleh National Institute of Health Research and Development, Ministry of Health of Republic of Indonesia
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