It is the cache of It is a snapshot of the page. The current page could have changed in the meantime.
Tip: To quickly find your search term on this page, press Ctrl+F or ⌘-F (Mac) and use the find bar.

Management of patients with atrial fibrillation at high risk of stroke
skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site


Management of patients with atrial fibrillation at high risk of stroke: current treatment options


(4210) Total Article Views

Authors: Edwards D, Harris K, Mant J

Published Date June 2012 Volume 2012:3 Pages 35 - 47

Duncan Edwards, Keara Harris, Jonathan Mant
Primary Care Unit, University of Cambridge, Cambridge, UK

Abstract: Atrial fibrillation (AF) is common, and is associated with an increased risk of stroke. Patients' absolute risk of stroke depends on the presence or absence of additional risk factors as well as AF, including prior thromboembolism, increased age, hypertension, diabetes, structural heart disease, and female sex. The risk to benefit ratio of stroke prevention therapy differs according to the patients' absolute risk. There is evidence that even those with an estimated annual stroke risk of 2%–4%, who were once classified as medium risk, would benefit from anticoagulation and should be included in an expanded high-risk category. Alternatives to anticoagulation include the restoration of sinus rhythm and left atrial appendage surgery, but these may not be suitable for many high-risk patients with comorbidities. Antiplatelets are substantially less effective than anticoagulation and cause similar rates of bleeding. Self-monitoring and computerized decision support increases the time in therapeutic range and effectiveness of vitamin K antagonists. Novel oral anticoagulants including dabigatran, rivoraxaban, and apixaban have been shown to be noninferior to warfarin, do not require monitoring, and increase the prescribing options for stroke prevention in AF.

Keywords: stroke prevention, atrial fibrillation, anticoagulants, primary prevention

Post to:
Cannotea Citeulike Facebook LinkedIn Twitter

Readers of this article also read:

  • ACC 2014

    We will attend the 2014 American College of Cardiology Scientific Session and Expo (ACC) on March 29-31, 2014. Stop by booth 3217 to talk with us.