 | | | | | | | World J Radiol. 2011 August 28; 3 (8) : 210-214. Published online 2011 August 28. doi: 10.4329/wjr.v3.i8.210. | | Copyright©2011 Baishideng Publishing Group Co., Limited. All rights reserved. Poul Erik Andersen's radiological work on Osteochondrodysplasias and interventional radiology Poul Erik Andersen. Poul Erik Andersen, Department of Radiology, Cardiovascular Section, Odense University Hospital, Sdr. Boulevard, DK-5000 Odense C, Denmark Received October 20, 2010; Revised April 11, 2011; Accepted April 18, 2011; | Abstract Poul Erik Andersen is a Professor and Interventional Radiologist at the University of Southern Denmark, Odense and Odense University Hospital, Denmark. His innovative and expertise is primarily in vascular interventions where he has introduced and developed many procedures at Odense University Hospital. His significant experience and extensive scientific work has led to many posts in the Danish Society of Interventional Radiology, the European Society of Radiology and the Cardiovascular and Interventional Radiological Society of Europe, where he is a fellow and has passed the European Board of Interventional Radiology - The European qualification in Interventional Radiology. Keywords: Biography, Clinical competence, Education, Interventional, Radiology | INTRODUCTION AND EDUCATIONAL EXPERIENCE Dr. Poul Erik Andersen (Figure ) is a Professor of Radiology at the University of Southern Denmark, Odense. He received his Medical degree from the University of Southern Denmark, Odense in 1974, and passed the Educational Council for Foreign Medical Graduates, Philadelphia, Penn., USA exam in 1975. He was certified as a Specialist in Radiology in 1982. Since 1983, Dr. Andersen has been Chief Radiologist/Consultant of the Department of Radiology, Cardiovascular Section at Odense University Hospital. | ACADEMIC ACHIEVEMENTS Cardiopulmonary diseases Poul Erik Andersen’s scientific research was primarily on cardiopulmonary diseases[ 1 - 22] including left ventricular function examinations in ischemic heart diseases, before and after coronary bypass surgery and coronary angioplasty (PCI) and in cardiomyopathy[ 4 - 6 , 9 , 12 - 16]. He and his group demonstrated that revascularization of the myocardium improved left ventricular function. Osteochondrodysplasias Subsequently, his research was on the epidemiological and radiological findings in congenital osteochondrodysplasias[ 23 - 43] where he was the first to describe heterogeneity and to define two radiological subtypes of autosomal dominant osteopetrosis[ 32 , 33]. These two radiological subtypes were later shown to correlate with two biochemical and genetically well defined subtypes[ 35 , 43]. Furthermore, he demonstrated that osteochondrodysplasias have a higher prevalence in the population than previously supposed, and that the incidence of chondrodysplasia (achondroplasia) was less seldom than generally recognized. These findings resulted in his Ph.D. degree in 1987 from the University of Southern Denmark, Odense with the thesis: “Generalized Osteochondrodysplasias and other Syndromes with Characteristic Bone Manifestations in the County of Fyn, Denmark. A Clinical, Radiological, and Epidemiological Investigation”[ 30 , 39 , 42]. Interventional vascular radiology, embolizations In recent years, Poul Erik Andersen’s research has been focussed on interventional vascular radiology, especially embolizations[ 44 - 62]. He and his group formed a Danish National Centre for patients with hereditary haemorrhagic telangiectasia (HHT) (Mb. Osler) in which treatment of pulmonary arteriovenous malformations (PAVM) by embolization was introduced in 1996[ 44 , 45] and plays a central role in the treatment of these patients[ 44 - 47 , 50 , 54 , 56 , 58 , 62]. He has introduced several different embolization techniques for the embolization of PAVM, such as detachable silicone balloons, coils, microcoils, detachable coils, and vascular plugs (Figure ). The group has also performed epidemiologic studies on HHT [44,45,48], and recently at least three genetic subtypes of HHT have been demonstrated[ 52]. Poul Erik Andersen and his interventional group are also leading the treatment of uterine fibroids in Denmark using uterine artery embolization, which was introduced in 1999[ 48]. Furthermore, they perform many other embolization procedures for conditions such as gastrointestinal bleeding, bleeding in trauma patients, haemoptysis, and in many tumour types. Embolization may be life saving in acute cases such as those with haemoptysis[ 55], gastrointestinal bleeding[ 60 , 61] and bleeding due to trauma. These embolization treatments are minimally-invasive techniques which, to a great extent, have substituted the corresponding conventional surgical procedures, and include the treatment of PAVM, as well as many cases of uterine fibroids, gastrointestinal bleeding, and the treatment of haemoptysis and patients with bleeding due to trauma. Interventional radiology, angioplastics: Should this be angioplasty? Within the field of Interventional Vascular Radiology, Dr. Andersen has been innovative and has introduced the use of percutaneous transluminal angioplastics in peripheral arteries at the Odense University Hospital in 1984, renal angioplastics in 1985[ 51 , 57], in coronary arteries (PTCA, PCI) in 1986, and peripheral vascular stents in 1991. He also introduced the first coronary stents in Denmark in 1992, the first carotid angioplastic in Denmark in 1993[ 21], and the first carotid stent implantation in Scandinavia in 1996. In addition, angioplastics in renal arteries in patients with renovascular hypertension is now the treatment of choice. He has refined these embolization techniques, including the use of microcatheters and has introduced many new embolization materials. Dr. Andersen has published more than one hundred research papers in peer reviewed journals and book chapters, and is the author of a radiological textbook (Chest Radiology) and editor of another radiological textbook (Musculoskeletal Radiology). Dr. Andersen has presented more than one hundred papers and lectures at several Postgraduate Courses and at the Danish, Nordic, European, and World Congresses. He has been an invited speaker and has chaired and moderated at several international meetings, including the European Congresses of Radiology (ECR) in Vienna and the Annual Meetings and Postgraduate Courses of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). He is a member of the abstract reviewer group in both ECR and CIRSE and a member of the faculty for CIRSE. He was the local Meeting Chairman of CIRSE in Copenhagen in 2008 and a member of the Executive Committee and Scientific Programme Planning Committee for CIRSE. He is a subcommittee member and has assisted in the preparation of the educational programme, abstract review and grading in the topics: “Cardiac” and “Interventional Radiology” at several European Congresses of Radiology and is Chairman of the Interventional Radiology Subcommittee 2011. He has been a peer reviewer for several scientific journals including Danish Medical Journal (Ugeskr. Laeger), Acta Orthopaedica Scandinavica, American Journal of Medical Genetics, Acta Radiologica, European Respiratory Journal, European Radiology, European Journal of Vascular and Endovascular Surgery, CardioVascular & Interventional Radiology, European Journal of Cancer, Lung, Thorax, and World Journal of Radiology as well as research grant committees. As a leading radiologist, Dr. Andersen has received numerous awards from the Danish Society of Radiology, the Danish Heart Association, the James Polack’s Foundation, the Disabled Foundation, and Poul Lundbeck’s Foundation. Dr. Andersen has been a lecturer at the University of Southern Denmark, Odense in Anatomy and Radiology since 1979 and since 1985 has held the position of Associate Professor at the Institute of Radiology, University of Southern Denmark, Odense and from 2011 Professor of Radiology, University of Southern Denmark, Odense. Since 1994, he has been a member and since 2000 a Fellow of CIRSE, and has passed the European Board of Interventional Radiology - The European qualification in Interventional Radiology. He is a member of the Danish Society of Radiology and Danish Society of Interventional Radiology, and Chairman of the Danish Society of Interventional Radiology from 2002 - 2006. He has arranged and led several postgraduate courses and scientific meetings in the Danish Society of Interventional Radiology and has held in all nine uterine fibroid embolization (UFE) Workshops at Odense University Hospital for Radiologists from Denmark, Sweden, Finland, Italy, and Holland and has given simulator training as a Proctor on UFE at the CIRSE meeting in 2010. He has had many positions in the Danish Society of Radiology and has for many years been Chairman of the Educational Committee for Radiologists. Since 2010, Dr. Andersen has been Co-Editor of World Journal of Radiology. | CONCLUSION Interventional radiology (IR) techniques are patient-friendly minimally-invasive procedures which in many cases can substitute for the corresponding surgical treatments. Patients treated with IR generally have a shorter hospital stay and recovery than patients treated with the corresponding surgical procedures. IR involves very selective treatments with few complications. IR is now a UEMS recognized and fast growing radiological subspecialty with great research potential. | | | References 1. Andersen PE, Andersen LH, Jest P. The chest radiograph in chronic obstructive lung disease compared with measurements of single-breath nitrogen washout and spirometry. Clin Radiol. 1982; 33:51-55. [PubMed] 2. Andersen PE Jr, Nielsen SM, Jørgensen EØ. Pulmonary auscultation related to chest film findings in infants and children. Danish Medical Bulletin. 1982; 29:80-83. 3. Andersen PE, Heslet L, Elle B, Bastholt L. Pulmonary airflow obstruction following lymphography. Acta Radiol Diagn (Stockh). 1982; 23:639-642. [PubMed] 4. Møller M, Thayssen P, Alstrup P, Haghfelt T, Andersen JR PE. The effect of coronary artery bypass surgery on ventricular arrhytmias. Eur Heart J. 1983; 4:26-30. 5. Beckmann J, Johansen L, Richardt C, Blichert-Toft M. Psychological reactions in younger women operated on for breast cancer. Amputation versus resection of the breast with special reference to body-image, sexual identity and sexual function. Dan Med Bull. 1983; 30 Suppl 2:10-13. [PubMed] 6. Andersen PE, Thayssen P, Haghfelt T. The effect of coronary bypass surgery on anginal state and left ventricular function. Dan Med Bull. 1983; 30:190-195. [PubMed] 7. Andersen PE, Lorentzen JE. Comparison of computed tomography and aortography in abdominal aortic aneurysms. J Comput Assist Tomogr. 1983; 7:670-673. [PubMed] 8. Andersen PE Jr, Nielsen SM, Jørgensen EØ. Pulmonary Auscultation Related to Chest Film Findings in Infants and Children. Int Synopses Pediatr Dig. 1983; 14:15. 9. Andersen PE, Thayssen P. The effect of coronary bypass surgery on segmental left ventricular function. Dan Med Bull. 1984; 31:503-507. [PubMed] 10. Andersen PE. Brachialis Seldinger puncture with use of introducer sheath. Br J Radiol. 1985; 58:777-778. [PubMed] 11. Høst A, Halken S, Andersen PE. Reversibility of cortical hyperostosis following long-term prostaglandin E1 therapy in infants with ductus-dependent congenital heart disease. Pediatr Radiol. 1988; 18:149-153. [PubMed] 12. Berning J, Rokkedal Nielsen J, Launbjerg J, Fogh J, Mickley H, Andersen PE. Rapid estimation of left ventricular ejection fraction in acute myocardial infarction by echocardiographic wall motion analysis. Cardiology. 1992; 80:257-266. [PubMed] 13. Egstrup K, Andersen PE. Transient myocardial ischemia during nifedipine therapy in stable angina pectoris, and its relation to coronary collateral flow and comparison with metoprolol. Am J Cardiol. 1993; 71:177-183. [PubMed] 14. Andersen PE, Bolstad B, Berg KJ, Justesen P, Thayssen P, Kloster YF. Iodixanol and ioxaglate in cardioangiography: a double-blind randomized phase III study. Clin Radiol. 1993; 48:268-272. [PubMed] 15. Junker A, Thayssen P, Nielsen B, Andersen PE. The hemodynamic and prognostic significance of echo-Doppler-proven mitral regurgitation in patients with dilated cardiomyopathy. Cardiology. 1993; 83:14-20. [PubMed] 16. Ravkilde J, Nissen H, Mickley H, Andersen PE, Thayssen P, Hørder M. Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris. Am Heart J. 1994; 127:13-20. [PubMed] 17. Licht P, Jacobsen E, Lerbjerg G, Andersen PE, Alstrup P. Cephalic veins in coronary artery bypass surgery. Eur J Cardiothorac Surg. 1996; 10:327-330. [PubMed] 18. Christensen ED, Johansen JB, Thayssen P, Andersen PE, Alstrup P. Treatment of anomalous origin of the left coronary artery from the pulmonary artery in adulthood. Cardiology. 1996; 87:260-262. [PubMed] 19. Djurhuus MS, Klitgaard NA, Jensen BM, Andersen PE, Schrøder HD. Multiple anomalies, hypokalaemic paralysis and partial symptomatic relief by terbutaline. Acta Paediatr. 1998; 87:475-477. [PubMed] 20. Mølstad P, Myreng Y, Golf S, Sirnes PA, Kassis E, Abilgaard U, Andersen PE, Thuesen L. The Barath Cutting Balloon versus conventional angioplasty. A randomized study comparing acute success rate and frequency of late restenosis. Scand Cardiovasc J. 1998; 32:79-85. [PubMed] 21. Andersen PE, Justesen P, Elle B, Røder OC. Carotid artery stenting. J Interv Radiol. 1998; 13:71-76. 22. Birkebaek NH, Hansen LK, Elle B, Andersen PE, Friis M, Egeblad M, Damgaard-Pedersen K, Nielsen NT, Oxhøj H. Chest roentgenogram in the evaluation of heart defects in asymptomatic infants and children with a cardiac murmur: reproducibility and accuracy. Pediatrics. 1999; 103:E15. [PubMed] 23. Andersen PE Jr, Schwartz W. Doppelseitige Synostosen zwischen dem Os trapezoideum und dem Os capitatum bei Turner-Syndrom. der Radiologe. 1979; 19:499-501. 24. Andersen PE. Achondrogenesis type II in twins. Br J Radiol. 1981; 54:61-65. [PubMed] 25. Frandsen PA, Andersen PE. Treatment of displaced fractures of the femoral neck. Smith-Petersen osteosynthesis versus sliding-nail-plate osteosynthesis. Acta Orthop Scand. 1981; 52:547-552. [PubMed] 26. Schwartz W, Poulsen HK, Andersen PE. [Sirenomelia--the caudal regression syndrome (author's transl)]. Monatsschr Kinderheilkd. 1982; 130:565-566. [PubMed] 27. Andersen PE, Andersen PE, van der Kooy P. Dose reduction in radiography of the spine in scoliosis. Acta Radiol Diagn (Stockh). 1982; 23:251-253. [PubMed] 28. Justesen P, Anderson PE. Radiologic manifestations in alcaptonuria. Skeletal Radiol. 1984; 11:204-208. [PubMed] 29. Frandsen PA, Andersen PE, Christoffersen H, Thomsen PB. Osteosynthesis of femoral neck fracture. The sliding-screw-plate with or without compression. Acta Orthop Scand. 1984; 55:620-623. [PubMed] 30. Poul Erik Andersen jr. Generaliserede skeletdysplasier og andre syndromer med karakteristiske skeletmanifestationer i Fyns amt. En klinisk, radiologisk og epidemiologisk undersøgelse. PhD database. 2006;. 31. Andersen PE, Justesen P. Chondrodysplasia punctata. Report of two cases. Skeletal Radiol. 1987; 16:223-226. [PubMed] 32. Andersen PE, Bollerslev J. Heterogeneity of autosomal dominant osteopetrosis. Radiology. 1987; 164:223-225. [PubMed] 33. Andersen PE, Hauge M, Bang J. Dyssegmental dysplasia in siblings: prenatal ultrasonic diagnosis. Skeletal Radiol. 1988; 17:29-31. [PubMed] 34. Bollerslev J, Andersen PE. Radiological, biochemical and hereditary evidence of two types of autosomal dominant osteopetrosis. Bone. 1988; 9:7-13. [PubMed] 35. Andersen PE, Schantz K, Bollerslev J, Justesen P. Bilateral femoral head dysplasia and osteochondritis. Multiple epiphyseal dysplasia tarda, spondylo-epiphyseal dysplasia tarda, and bilateral Legg-Perthes disease. Acta Radiol. 1988; 29:705-709. [PubMed] 36. Schantz K, Andersen PE, Justesen P. Spondyloepiphyseal dysplasia tarda. Report of a family with autosomal dominant transmission. Acta Orthop Scand. 1988; 59:716-719. [PubMed] 37. Bollerslev J, Grøntved A, Andersen PE. Autosomal dominant osteopetrosis: an otoneurological investigation of the two radiological types. Laryngoscope. 1988; 98:411-413. [PubMed] 38. Andersen PE, Hauge M. Congenital generalised bone dysplasias: a clinical, radiological, and epidemiological survey. J Med Genet. 1989; 26:37-44. [PubMed] 39. Bollerslev J, Andersen PE. Fracture patterns in two types of autosomal-dominant osteopetrosis. Acta Orthop Scand. 1989; 60:110-112. [PubMed] 40. Andersen PE. Prevalence of lethal osteochondrodysplasias in Denmark. Am J Med Genet. 1989; 32:484-489. [PubMed] 41. Andersen PE, Hauge M. Osteogenesis imperfecta: a genetic, radiological, and epidemiological study. Clin Genet. 1989; 36:250-255. [PubMed] 42. Van Hul E, Gram J, Bollerslev J, Van Wesenbeeck L, Mathysen D, Andersen PE, Vanhoenacker F, Van Hul W. Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13. J Bone Miner Res. 2002; 17:1111-1117. 43. Van Hul E, Gram J, Bollerslev J, Van Wesenbeeck L, Mathysen D, Andersen PE, Vanhoenacker F, Van Hul W. Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13. J Bone Miner Res. 2002; 17:1111-1117. [PubMed] 44. Andersen PE, Kjeldsen AD, Oxhøj H, Vase P, White RI. Embolotherapy for pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Acta Radiol. 1998; 39:723-726. [PubMed] 45. Kjeldsen AD, Oxhøj H, Andersen PE, Elle B, Jacobsen JP, Vase P. Pulmonary arteriovenous malformations: screening procedures and pulmonary angiography in patients with hereditary hemorrhagic telangiectasia. Chest. 1999; 116:432-439. [PubMed] 46. Andersen PE, Kjeldsen AD, Oxhøj H, Vase P, White RI. Embolotherapy for pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Acta Radiol. 1998; 39:723-726. [PubMed] 47. Kjeldsen AD, Oxhøj H, Andersen PE, Elle B, Jacobsen JP, Vase P. Pulmonary arteriovenous malformations: screening procedures and pulmonary angiography in patients with hereditary hemorrhagic telangiectasia. Chest. 1999; 116:432-439. [PubMed] 48. Andersen PE, Lund N, Justesen P, Munk T, Elle B, Floridon C. Uterine artery embolization of symptomatic uterine fibroida . Initial success and short-term results. Acta Radiol. 2001; 42:234-238. [PubMed] 49. Baudier JF, Licht PB, Røder O, Andersen PE. Endovascular treatment of severe symptomatic stenosis of the internal carotid artery: early and late outcome. Eur J Vasc Endovasc Surg. 2001; 22:205-210. [PubMed] 50. Gaïni S, Shahin AD, Andersen PE. Brain abscess and hypoxia in a previously healthy young female. Scand J Infect Dis. 2005; 37:301-303. [PubMed] 51. Andersen PE, Rohr N. Endovascular exclusion of renal artery aneurysm. Cardiovasc Intervent Radiol. 2005; 28:665-667. [PubMed] 52. Kjeldsen AD, Møller TR, Brusgaard K, Vase P, Andersen PE. Clinical symptoms according to genotype amongst patients with hereditary haemorrhagic telangiectasia. J Intern Med. 2005; 258:349-355. [PubMed] 53. Licht PB, Andersen PE. Pneumonectomized top athlete. Eur J Cardiothorac Surg. 2005; 28:767. [PubMed] 54. Andersen PE, Kjeldsen AD. Clinical and radiological long-term follow-up after embolization of pulmonary arteriovenous malformations. Cardiovasc Intervent Radiol. 2006; 29:70-74. [PubMed] 55. Andersen PE. Imaging and interventional radiological treatment of hemoptysis. Acta Radiol. 2006; 47:780-792. [PubMed] 56. Andersen PE, Kjeldsen AD. Occlusion of pulmonary arteriovenous malformations by use of vascular plug. Acta Radiol. 2007; 48:496-499. [PubMed] 57. Øvrehus KA, Andersen PE, Jacobsen IA. Treatment of renovascular hypertension by transluminal angioplasty--13 years experience in a single centre. Blood Press. 2007; 16:335-340. [PubMed] 58. Andersen PE, Kjeldsen AD. Long-term follow-up after embolization of pulmonary arteriovenous malformations with detachable silicone balloons. Cardiovasc Intervent Radiol. 2008; 31:569-574. [PubMed] 59. Mikkelsen CS, Mikkelsen DB, Madsen HD, Andersen PE, Ravn P, Bygum A. Lymphangioleiomyomatosis in a patient with tuberous sclerosis and dysregulated diabetes mellitus. Acta Derm Venereol. 2009; 89:218-219. [PubMed] 60. Duvnjak S, Andersen PE. The effect of transcatheter arterial embolisation for nonvariceal upper gastrointestinal bleeding. Dan Med Bull. 2010; 57:A4138. [PubMed] 61. Andersen PE, Duvnjak S. Endovascular treatment of nonvariceal acute arterial upper gastrointestinal bleeding. World J Radiol. 2010; 2:257-261. [PubMed] 62. Andersen PE, Kjeldsen AD. Interventional treatment of pulmonary arteriovenous malformations. World J Radiol. 2010; 2:339-344. [PubMed] | | | | |
