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Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography | Naid | European Journal of Chemistry

Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography

Tadjuddin Naid, Wahyu Rizandi Syukur, Amran Ilyas, Seniwati Dali, Baharuddin Hamzah

Abstract


The study was conducted with the purpose to develop and validate a high performance liquid chromatography method with UV detector to determine ketoprofen content in tablet preparation using ethanol-phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD = 0.5302 ppm and LOQ = 1.7676 ppm.

4_1_58_60

Keyword(s)


Conformity; Optimization; Ketoprofen; Phosphate buffer; Validation method; High performance liquid chromatography

European Journal of Chemistry, 4 (1), (2013), 58-60

Full Text:

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DOI: http://dx.doi.org/10.5155/eurjchem.4.1.58-60.678


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