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Rational Pharmacotherapy in CardiologyEfficacy of fixed combination of valsartan, amlodipine and hydrochlorothiazide in complex therapy of the patient of very high cardiovascular risk

Efficacy of fixed combination of valsartan, amlodipine and hydrochlorothiazide in complex therapy of the patient of very high cardiovascular risk

I.M. Sokolov*, N.A. Zheleznyakova

Saratov State Medical University named after V.I. Razumovskii. Bolshaya Kazachia st. 112, Saratov, 410012 Russia

The high prevalence of arterial hypertension in association with high and very high cardiovascular risk requires widespread use of combined therapy. Current approaches to selection of combination components of antihypertensive drugs are based the efficacy of these drugs proven in multicenter randomized clinical trials. The triple combination of calcium antagonist, angiotensin II receptor blocker and thiazide diuretic is regarded as the best option for combined therapy in patients with arterial hypertension and ischemic heart disease to reduce cardiovascular risk.

Key words: fixed combination, valsartan, amlodipine, hydrochlorothiazide, angina, arterial hypertension.

Rational Pharmacother. Card. 2011;8(1):68-74

* Corresponding author: docsim@bk.ru


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«Stolichnaya Izdatelskaya Kompaniya»

ISSN 1819-6446(Print) ISSN 2225-3653 (Online)