Synthesis and evaluation of anti-leishmania activity of analogs isoxazoles derivatives of grandisin and veraguensin neolignans
Ozildéia Soares, Maria Letícia . F. Silva, João Vitor D. Martins, Gabriela R. Hurtado, Luiz H. Viana, Adriano C. M. Baroni
Abstract
Using the concept of bioisosterismo, the new analogs isoxazole were designed from the molecular modification of grandisin and veraguensin neolignans, which have a grouping that is a furan ring bioisóstero isoxazole. In order to obtain more potent compounds, and better physical and chemical characteristics, our research group synthesized six analogues isoxazole neolignans. These reactions were performed of 1,3-dipolar cycloaddition between oximes chlorine and terminal acetylenes previously synthesized. The reaction system CuSO4.5H2O/Ascorbate Sodium / KHCO3, CH2Cl2/THF was used, and under this condition were obtained isoxazole six analogues with yields ranging from 71% To 90%. The compounds were sent for testing anti-Leishmania activity and anti-trypanosome.
Keywords
bioisosterism; isoxazole analogs; anti-leishmania
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