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Rational Pharmacotherapy in CardiologyGenetic predictors of idiopathic sick sinus syndrome
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Genetic predictors of idiopathic sick sinus syndrome

A. A. Chernova*, S. Yu. Nikulina, S. S. Tret'yakova

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 Russia

Published data demonstrating genetic determination of sick sinus syndrome is presented. The definition of this pathology is presented; the main symptoms are described, as well as genes that influence the development of idiopathic sick sinus syndrome, their polymorphisms and role in disorders of the cardiovascular system.

Key words: idiopathic sinus syndrome, genetic determinism, myosin heavy chains (MYH6) gene, SCN5A, HCN4, konneksin-40, ADRA2B gene, endothelial NO-synthase gene.

Rational Pharmacother. Card. 2012;8(6): 804-809

*Corresponding author: anechkachernova@yandex.ru  


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© 2007 — 2014 «Rational Pharmacotherapy in Cardiology»
«Stolichnaya Izdatelskaya Kompaniya»

ISSN 1819-6446(Print) ISSN 2225-3653 (Online)

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