This study is carried out on Wistar rats to evaluate the hepatoprotective activity of Argemone mexicana L aerial part extracts against CCL ₄ induced acute liver damages. The areal part of the plant was extracted by methanol and water using soxhlet, rotary evaporator and freeze drying apparatus. Hepatic injury was achieved by injecting 3 mL/kg s.c. of CCL ₄ in equal volume proportion with olive oil. The aqueous and methanol extracts of Argemone mexicana areal part were given at different doses, 100, 200, 400 mg/kg/day Methanol extract, and 400 mg/kg/day orally of aqueous extract for 5 days under CCL ₄ induction at 3rd day. The significance of differences between means was compared among the groups using Independent-sample T-test with probability value. The methanol extract at 100 mg/kg offered significant hepatoprotective activity (p<0.05) by reducing the serum marker enzyme, like Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyrovate Transaminase (SGPT) and Alkaline Phosphatase (ALP). Histopathlogical studies further confirmed the hepatoprotective activity of 100 mg/kg methanol extract. Argemone mexicana L. at dose 100 mg/kg indeed has a reasonable potential in healing liver parenchyma and regeneration of liver cells hence it may acts as a potent liver tonic. The results obtained were compared with silymarin (70 mg/kg.oral), the standard drug, which shown recovery toward normalization almost like that of silymarin, therefore, we recommend for further studies to isolate the pure component and the mechanism that displayed the hepatoprotective activity for making standard drug.