Helicobacter pylori eradication induce platelet recovery in idiopathic thrombocytopenic purpura
Abstract
Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (1TP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 x IO^L-120 x IO’VL) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pylori infection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a non immunosuppressive treatment in some ITP patients. (Blood 2001; 97: 812-814)
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PDFDOI: http://dx.doi.org/10.4081/reumatismo.2001.330
Submitted: 2011-03-15 12:13:34
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Reumatismo [eISSN 2240-2683] is the Official Journal of the Italian Society of Rheumatology (SIR). Founded in 1949. Available In Medline, Embase, and other online databases. All credits and honors to PKP for their OJS.