It is the cache of ${baseHref}. It is a snapshot of the page. The current page could have changed in the meantime.
Tip: To quickly find your search term on this page, press Ctrl+F or ⌘-F (Mac) and use the find bar.

In vivo characterization of ischemic retina in diabetic retinopathy
skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

14789

In vivo characterization of ischemic retina in diabetic retinopathy



Original Research

(6896) Total Article Views


Authors: Lukas Reznicek, Marcus Kernt, Christos Haritoglou, et al

Published Date December 2010 Volume 2011:5 Pages 31 - 35
DOI: http://dx.doi.org/10.2147/OPTH.S13850

Lukas Reznicek, Marcus Kernt, Christos Haritoglou, Anselm Kampik, Michael Ulbig, Aljoscha S Neubauer
Department of Ophthalmology, Ludwig Maximilian University, Munich, Germany

Objective: The aim of this article is to characterize pathomorphologic changes within particular layers of fluorescein angiographically 'ischemic' compared to 'nonischemic' retina in patients with diabetic retinopathy.
Methods: Cross-sectional images of ischemic retinal areas were obtained using Heidelberg Spectralis optical coherence tomography (OCT). Presumed retinal ischemia was defined as focal hypofluorescence in early or early and late phase fluorescein angiography. Pathomorphologic changes on OCT were evaluated and the thickness of retinal layers measured and compared with nonischemic retina at corresponding topographic locations in a matched-pairs design based on 22 eyes (mean age 64 ± 14).
Results: In all eyes, based on spectral domain-OCT cross-section images, the retina layers in ischemic retinal areas could be segmented. Total retinal thickness was significantly increased in ischemic compared to nonischemic areas (381 ± 94 µm versus 323 ± 89 µm, P = 0.005). Middle retinal layers (inner nuclear layer, outer plexiform layer, and outer nuclear layer) were significantly thickened in retinal ischemic areas (215 ± 82 µm versus 168 ± 62 µm, P = 0.002). The inner retinal layers (retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer) showed a nonsignificant change (117 ± 53 µm versus 98 ± 30 µm), while the outer layers were slightly thinned (photoreceptors plus retinal pigment epithelium layer; 51 ± 9 µm versus 57 ± 8 µm, P = 0.02) in ischemic versus nonischemic retina.
Conclusions: Ischemic diabetic retina seems to be thickened due to thickening of, in particular, middle retinal layers, which can be measured with high-resolution OCT.

Keywords: OCT, Spectralis OCT, fluorescein angiography, diabetic retinopathy, ischemic retina, retinal thickness, retinal layers


Post to:
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter

 

Other articles by Dr Lukas Reznicek


Readers of this article also read: