It is the cache of http://www.dovepress.com/hiv-1-evolution-drug-resistance-and-host-genetics-the-indian-scenario-a2938. It is a snapshot of the page. The current page could have changed in the meantime.
Tip: To quickly find your search term on this page, press Ctrl+F or ⌘-F (Mac) and use the find bar.

HIV-1 evolution, drug resistance, and host genetics: The Indian scenar
skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

14853

HIV-1 evolution, drug resistance, and host genetics: The Indian scenario



Review

(5904) Total Article Views


Authors: U Shankarkumar, A Pawar, K Ghosh

Published Date March 2009 Volume 2009:1 Pages 1 - 4
DOI: http://dx.doi.org/10.2147/VAAT.S4974

U Shankarkumar, A Pawar, K Ghosh

National Institute of Immunohaematology (ICMR), KEM Hospital, Parel, Mumbai, Maharashtra, India

Abstract: A regimen with varied side effects and compliance is of paramount importance to prevent viral drug resistance. Most of the drug-resistance studies, as well as interpretation algorithms, are based on sequence data from HIV-1 subtype B viruses. Increased resistance to antiretroviral drugs leads to poor prognosis by restricting treatment options. Due to suboptimal adherence to antiretroviral therapy there is an emergence of drug-resistant HIV-1 strains. The other factors responsible for this viral evolution are antiretroviral drug types and host genetics, especially major histocompatibility complex (MHC). Both primary and secondary drug resistances occur due to mutations in specific epitopes of viral protein regions which may influence the T cell recognition by immune system through MHC Class I and class II alleles. Mutations in viral epitopes enable the virus to escape the immune system. New drugs under clinical trials are being added but their exorbitant costs limit their access in developing countries. Thus the environmental consequences and, the impact of both viral and host genetic variations on the therapy in persons infected with HIV-1 clade C from India need to be determined.

Keywords: HIV-1 C drug resistance, virus adaptation, HARRT, India




Post to:
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter


Readers of this article also read:

  • Testimonials

    "You do a tremendous job!!" Ruben Restrepo, University of Texas Health Science Center, San Antonio.