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The role of the microenvironment in tumorimmune surveillance BACK TO CONTENTS PDF PREVIOUS NEXT
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Title

 

 

 

 

The role of the microenvironment in tumor immune surveillance 

Authors

Oluwadayo Oluwadara1, Luca Giacomelli2, Xenia Brant1, 3, Russell Christensen4, Raisa Avezova1, George Kossan1, Francesco Chiappelli1*

Affiliation

1School of Dentistry, Division of Oral Biology and Medicine; 2Tirrenian Stomatologic Institute, Lido di Camaiore (Lucca), Italy; 3CEO IPSEMG Belo Horizonte, Brazil; 4UCLA School of Dentistry, Division of Oral and Maxillofacial Pathology
 

Email

fchiappelli@dentistry.ucla.edu

Article Type

Hypothesis

 

Date

Received July 25, 2010; Accepted August 03, 2010; Published January 06, 2011
 

Abstract

The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O�Shea & Paul, 2010 ). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.
 

Keywords

Oral lichen planus, oral squamous cell carcinoma, proteomic voting, tumor microenvironment, T cell lineages, tumor immune surveillance

Citation

Oluwadara et al. Bioinformation 5(7): 285-290 (2011)

Edited by

Francesco chiappelli

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

Copyright

Publisher

 

Copyright Transfer Agreement

The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.

 

License

This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.