Bacterial superantigens and organism physiological status: a theoretical approach
Abstract
: The present review was undertaken in order to present the bacterial superantigens influences on the organism
physiological status. In recent years, a great deal of a new knowledge about a group of microbial proteins known as
superantigens has been generated. These molecules have elicited tremendous interest because they interact with the
immune system in a nonconventional manner and can potentially trigger diseases such as toxic shock, food poisoning,
and autoimmunity. Moreover, evidence from clinical observations, animal models of disease, and studies with cell lines
indicate an intimate association between bacteria (and bacterial products) and the pathophysiology of many nervous
disorders. In summary, knowing the immunological and biological effects of superantigens will help to discern the
mechanism of pathogenesis of a number of diseases linked to microbial infections and will offer new possibilities for the
development of novel and effective therapeutic strategies.
physiological status. In recent years, a great deal of a new knowledge about a group of microbial proteins known as
superantigens has been generated. These molecules have elicited tremendous interest because they interact with the
immune system in a nonconventional manner and can potentially trigger diseases such as toxic shock, food poisoning,
and autoimmunity. Moreover, evidence from clinical observations, animal models of disease, and studies with cell lines
indicate an intimate association between bacteria (and bacterial products) and the pathophysiology of many nervous
disorders. In summary, knowing the immunological and biological effects of superantigens will help to discern the
mechanism of pathogenesis of a number of diseases linked to microbial infections and will offer new possibilities for the
development of novel and effective therapeutic strategies.
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