-
International Journal of Nanomedicine
- About Dovepress
Open access peer-reviewed scientific and medical journals.
- Open Access
Dove Medical Press is now a member of the Open Access Initiative
- An Author's Guide
A guide to help authors get their paper published.
- Advocacy
Support Open Access and Dove Press
- Reprints
Promotional Article Monitoring - further details
- Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Tumor targeting using liposomal antineoplastic drugs
Review
(6343) Total Article Views
Authors: Jörg Huwyler, Jürgen Drewe, Stephan Krähenbühl
Published Date March 2008 Volume 2008:3(1) Pages 21 - 29
DOI: http://dx.doi.org/10.2147/IJN.S1253
Jörg Huwyler1, Jürgen Drewe2, Stephan Krähenbühl2
1University of Applied Sciences Northwestern Switzerland, Institute of Pharma Technology, Muttenz, Switzerland; 2Department of Research and Division of Clinical Pharmacology, University Hospital Basel, Basel, Switzerland
Abstract: During the last years, liposomes (microparticulate phospholipid vesicles) have beenused with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumordrugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers for active targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side-effects. The present article reviews the principles of different liposomal technologies and discusses current trends in this field of research.
Keywords: tumor targeting, antineoplastic drugs, liposomes, pegylation, steric stabilization, immunoliposomes
Post to:
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Readers of this article also read:
- ASNM conference 2014
Join us at the American Society for Nanomedicine Conference in Maryland, March 28th - 30th 2014.
- Impact Factors
3.486 Drug Design
3.463 Int J Nanomedicine
2.651 Clin Interv Aging
2.073 Onco Targets Ther
2.000 Neuropsychiatr Dis
1.405 Ther Clin Risk Manag
1.333 Patient Preference - Have an opinion about one of our articles?
We encourage you to write a letter to the editor.
- Interested in being a peer-reviewer?
Click here to register.
- Pre-Submissions
Authors are welcome to send an abstract or draft manuscript to obtain a view from the Editor about the suitability of their paper. Please email here and include which journal you are interested in submitting your manuscript to. Our Editors will do a quick review of your paper and advise if they believe it is appropriate for submission to their journal.
- Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy
- Fungus-mediated biological synthesis of gold nanoparticles: potential in detection of liver cancer
- Applications of gold nanoparticles in cancer nanotechnology
- Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy
