It is the cache of ${baseHref}. It is a snapshot of the page. The current page could have changed in the meantime.
Tip: To quickly find your search term on this page, press Ctrl+F or ⌘-F (Mac) and use the find bar.

Application of 2-octyl-cyanoacrylate for corneal perforation and glauc
skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site

14789

Application of 2-octyl-cyanoacrylate for corneal perforation and glaucoma filtering bleb leak



Case Series

(1989) Total Article Views


Authors: Okabe M, Kitagawa K, Yoshida T, Koike C, Katsumoto T, Fujihara E, Nikaido T

Published Date March 2013 Volume 2013:7 Pages 649 - 653
DOI: http://dx.doi.org/10.2147/OPTH.S43106

Received: 22 January 2013
Accepted: 07 February 2013
Published: 28 March 2013
Motonori Okabe,1 Kiyotaka Kitagawa,2 Toshiko Yoshida,1 Chika Koike,1 Takeshi Katsumoto,2 Etsuko Fujihara,2 Toshio Nikaido1

1Department of Regenerative Medicine, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama, 2Division of Ophthalmology, Matsue Red Cross Hospital, Japanese Red Cross Society, Shimane, Japan

Background: This paper reports on the efficacy of a tissue adhesive, 2-octyl-cyanoacrylate, in the treatment of corneal perforation and glaucoma filtering bleb leak.
Methods: Two eyes from two patients with corneal perforation or laceration and two eyes from two patients with bleb leak were included. The patients underwent application of 2-octyl-cyanoacrylate onto the perforated or leaking site, and a hydrogel contact lens was applied as a bandage. We also evaluated the in vitro cell toxicity of 2-octyl-cyanoacrylate in HeLa cells.
Results: The two cases of corneal perforation were repaired within 22 days with one application of the tissue adhesive. The two cases of bleb leak were repaired with 2–4 applications of the tissue adhesive over 134 (range 17–134) days). There were no recurrences or adverse effects during a mean follow-up period of 12.7 months. In vitro testing revealed that 2-octyl-cyanoacrylate was markedly toxic to HeLa cells.
Conclusion: Four patients with corneal perforation or bleb leak were successfully managed using 2-octyl-cyanoacrylate tissue adhesive. This simple and easy surgical technique may become an alternative therapeutic option for corneal perforation or bleb leak, although several applications of this tissue adhesive may be required. Although 2-octyl-cyanoacrylate was toxic to HeLa cells, no adverse clinical effects were noted using this adhesive.

Keywords: corneal perforation, bleb leak, tissue adhesive, 2-octyl-cyanoacrylate



Post to:
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter


Readers of this article also read: