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Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety | Mohamed | European Journal of Chemistry

Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety

Mahmoud Abdallah Mohamed, Eman Kamal Ahmad Abdelall, Yasser Hassan Zaki, Abdou Osman Abdelhamid

Abstract


pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine and pyrimido[1,2-a] benzimidazole derivatives were synthesized by reaction of sodium salt of 3-hydroxy-(1-pyridin-2-yl)prop-2-en-1-one or sodium salt of 3-hydroxy-1-(pyridin-3-yl)prop-2-en-1-one with different heterocyclic amines in piperidenium acetate. Also, 3-amino-6-(2-pyridyl)thieno[2,3-b]pyridine derivatives were synthesized via reaction of pyridine-2-thione with various halogenated compounds. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral data, X-ray and alternative synthetic routes whenever possible.

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Keyword(s)


Pyridines; Thieno[2,3-b]pyridine; Pyrazolo[1,5-a]pyrimidine; Triazolo[1,5-a]pyrimidine; Pyrimido[1,2-a]benzimidazole; Piperidenium acetate

European Journal of Chemistry, 2 (4), (2011), 509-513

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DOI: http://dx.doi.org/10.5155/eurjchem.2.4.509-513.463


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