-
International Journal of Nanomedicine
- About Dovepress
Open access peer-reviewed scientific and medical journals.
- Open Access
Dove Medical Press is now a member of the Open Access Initiative
- An Author's Guide
A guide to help authors get their paper published.
- Advocacy
Support Open Access and Dove Press
- Reprints
Promotional Article Monitoring - further details
- Favored Author Program
Real benefits for authors, including fast-track processing of papers.
Research progress on siRNA delivery with nonviral carriers
Review
(12239) Total Article Views
Authors: Gao Y, Liu XL, Li XR
Published Date May 2011 Volume 2011:6 Pages 1017 - 1025
DOI: http://dx.doi.org/10.2147/IJN.S17040
Yan Gao*, Xin-Ling Liu*, Xiao-Rong LiTianjin Medical University Eye Center, Tianjin, China
*These two authors contributed equally to this work
Abstract: RNA interference is a powerful method for the knockdown of pathologically relevant genes. Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical genetic-therapy applications for many diseases. Unfortunately, siRNA duplexes are not ideal drug-like molecules. Problems hindering their effective application fundamentally lie in their delivery, stability, and off-target effects. Delivery systems provide solutions to many of the challenges facing siRNA therapeutics. Due to some fatal disadvantages of viral vectors, nonviral carriers have been studied extensively. Aside from liposomes, nanoparticles and cationic polymer carriers have exhibited improved in vivo stability, better biocompatibility, and efficiency for gene silencing with less cellular toxicity. They may represent a promising strategy for siRNA-based therapies, especially as nanomaterials. The present review also summarizes other methods of siRNA delivery and the side effects of the nanoparticles.
Keywords: small interfering RNA, nonviral vector, gene therapy, delivery system, nanoparticles, biocompatibility
Post to:
Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter
Readers of this article also read:
- ASNM conference 2014
Join us at the American Society for Nanomedicine Conference in Maryland, March 28th - 30th 2014.
- Impact Factors
3.486 Drug Design
3.463 Int J Nanomedicine
2.651 Clin Interv Aging
2.073 Onco Targets Ther
2.000 Neuropsychiatr Dis
1.405 Ther Clin Risk Manag
1.333 Patient Preference - Have an opinion about one of our articles?
We encourage you to write a letter to the editor.
- Interested in being a peer-reviewer?
Click here to register.
- Pre-Submissions
Authors are welcome to send an abstract or draft manuscript to obtain a view from the Editor about the suitability of their paper. Please email here and include which journal you are interested in submitting your manuscript to. Our Editors will do a quick review of your paper and advise if they believe it is appropriate for submission to their journal.
- Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy
- Fungus-mediated biological synthesis of gold nanoparticles: potential in detection of liver cancer
- Applications of gold nanoparticles in cancer nanotechnology
- Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy
