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Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia | Insciences Journal

About Stem Cells

The Stem Cells is a section published by the Insciences Journal (ISSN 1664-171X), an Open Access journal launched by Insciences Organisation. This section publishes High-quality original research papers and Reviews related to Stem Cells.

Insciences J. 2011, 1(1), 1-17;doi:10.5640/insc.01011

Full Research Paper, Section: Stem Cells

Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia

Elisabet Ametller1, Sílvia Busquets1,2, Gemma Fuster1, Maria T. Figueras1, Mireia Olivan1, Cibely Cristine Fontes de Oliveira1, Josep M. Argilés1,2, Francisco J. López-Soriano1,2 * email

1 Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
2 Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain

* Author to whom correspondence should be addressed.

Published: January 02, 2011

Complete Article

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PURPOSE: The development of cancer cachexia is the most
common manifestation of advanced malignant disease. METHOD: The
effects on muscle regeneration of 2-adrenoceptor agonist formoterol (0.3 mg/
kg) were tested in cachectic tumour-bearing rats (Yoshida AH-130 ascites
hepatoma). RESULTS: Administration of formoterol results in a significant
increase in the mass and protein content of tibialis muscle in tumour-bearing-rats.
This increase is associated with a decreased myogenin mRNA content together
with an increased Pax-7 gene expression. Bupivacaine treatment by local injection
results in an important reduction in tibialis weight together with significant
increases in Pax-7, myogenin and MyoD gene expression. Formoterol treatment
in bupivacaine-treated rats results in significant increases in Pax-7 together with
significant decreases in myogenin mRNA content, suggesting that this 2-agonist
is favouring muscle regeneration by stimulating the proliferation of satellite cells.
Altogether, the data reinforce the potential role of formoterol in the treatment of
muscle wasting diseases.

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