Insciences J. 2011, 1(1), 1-17;doi:10.5640/insc.01011
Full Research Paper, Section: Stem Cells
Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia
1 Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
2 Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
* Author to whom correspondence should be addressed.
Published: January 02, 2011
PURPOSE: The development of cancer cachexia is the most
common manifestation of advanced malignant disease. METHOD: The
effects on muscle regeneration of 2-adrenoceptor agonist formoterol (0.3 mg/
kg) were tested in cachectic tumour-bearing rats (Yoshida AH-130 ascites
hepatoma). RESULTS: Administration of formoterol results in a significant
increase in the mass and protein content of tibialis muscle in tumour-bearing-rats.
This increase is associated with a decreased myogenin mRNA content together
with an increased Pax-7 gene expression. Bupivacaine treatment by local injection
results in an important reduction in tibialis weight together with significant
increases in Pax-7, myogenin and MyoD gene expression. Formoterol treatment
in bupivacaine-treated rats results in significant increases in Pax-7 together with
significant decreases in myogenin mRNA content, suggesting that this 2-agonist
is favouring muscle regeneration by stimulating the proliferation of satellite cells.
Altogether, the data reinforce the potential role of formoterol in the treatment of
muscle wasting diseases.