doi: 10.5732/cjc.011.10245
Epigenetic changes in colorectal cancer
Yan Jia, Mingzhou Guo
Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing 100853, P. R. China; 2Medical College of Nankai University, Tianjin 300071, P. R. China
[Abstract] Epigenetic changes frequently occur in human colorectal cancer. Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer. Loss of imprinting(LOI) is associated with colorectal neoplasia. Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation. HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment. Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer. This review is mainly focused on DNA methylation, histone modification, and microRNA changes in colorectal cancer.
Chinese Journal of Cancer Volume 32・Issue 1・2013 Page: 21-30 [ PDF Full-text ]
