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Journal of Chinese Integrative Medicine Free Full Text
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Original Clinical Research
Journal of Chinese Integrative Medicine: Volume 7   July, 2009   Number 7

DOI: 10.3736/jcim20090704
Therapy for replenishing qi, nourishing yin and promoting blood circulation in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a randomized controlled trial
1. Sheng-lei QIU (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
2. Mei JIN (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China E-mail: jinmei622@yahoo.com.cn)
3. Jing-hong YI (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
4. Tian-gang ZHU (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
5. Xin QUAN (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
6. Yan LIANG (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
Background: No-reflow phenomenon after reperfusion treatment of acute myocardial infarction (AMI) is becoming more recognized today. The effective treatment for no-reflow has not been reported.
Objective: To observe the effects of traditional Chinese medicine (TCM) therapy for replenishing qi, nourishing yin, and promoting blood circulation on AMI patients undergoing percutaneous coronary intervention (PCI).
Design, setting, participants and interventions: This study was conducted from January 2005 to March 2006 using a double-blinded, randomized method. Thirty-five AMI patients (KillipⅠ-Ⅱ) were first diagnosed as ST segment elevation AMI and obtained primary PCI. They were recruited from People’s Hospital, Peking University. All patients’ symptoms accorded with qi-yin deficiency syndrome and blood stasis syndrome. They were randomly and double blindly divided into control group (18 cases) and treatment group (17 cases). The patients in the control group received Western medicine treatment, and the patients in the treatment group were treated with Western medicine plus American ginseng and Salviae miltiorrhizae preparations. They were all treated for 3 months.
Main outcome measures: Before and after 3-month treatment, the TCM symptoms were observed and scored. At the state of baseline and dobutamine stress, left ventricular ejection fraction (LVEF), wall motion score (WMS), WMS index and normal cardiac muscle percentage (NCMP), and the myocardial contrast echocardiography index k, which reflects myocardium microcirculation perfusion, were detected.
Results: After 3-month treatment, the TCM symptoms in the treatment group were improved as compared with the control group (χ2
4.118, P0.042). At the state of dobutamine stress, LVEF in the treatment group after treatment was higher than those in the control group (t2.130, P0.041) and before treatment (t2.345, P0.032). Although the number of the segments with increased k value was more than that in the control group, there was no significant difference.
Conclusion: TCM therapy for replenishing qi, nourishing yin and promoting blood circulation can improve the clinical symptoms and quality of life of the AMI patients undergoing PCI, and is beneficial to myocardium microcirculation. Thus, it may be an alternative cardioprotective treatment strategy for successful myocardial microcirculation in AMI patients after reperfusion.
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Qiu SL, Jin M, Yi JH, Zhu TG, Quan X, Liang Y. J Chin Integr Med. 2009; 7(7): 616-621. Received February 3, 2009; accepted April 24, 2009; published online July 15, 2009. Indexed/abstracted in and full text link-out at PubMed. Journal title in PubMed: Zhong Xi Yi Jie He Xue Bao. Free full text (HTML and PDF) is available at www.jcimjournal.com. Forward linking and reference linking via CrossRef. DOI: 10.3736/jcim20090704

 

Correspondence: Prof. Mei JIN; Tel: 010-52176535; E-mail: jinmei622@yahoo.com.cn
 

Full text of this article is in Chinese.

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