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Rational Pharmacotherapy in CardiologyACC/AHA clopidogrel clinical alert. What must be modern antiplatelet therapy?

ACC/AHA clopidogrel clinical alert. What must be modern antiplatelet therapy?

S.J. Martsevich*

State Research Center for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 Russia

Chair of Evidence Based Medicine, I.M. Setchenov First Moscow State Medical University. Petroverigsky per. 10, Moscow, 101990 Russia

The ACC/AHA clopidogrel clinical alert about the possibility of ineffective treatment with clopidogrel is discussed. The reason of this resistance to clopidogrel therapy and possible ways to overcome it is considered.

Key words: clopidogrel, genetic CYP2C19 polymorphism, antiplatelet therapy.

Rational Pharmacother. Card. 2010;6(4):607-609

*Corresponding author: smartsevich@gnicpm.ru


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ISSN 1819-6446(Print) ISSN 2225-3653 (Online)