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FABRICATION AND IN VITRO EVALUATION OF OSMOTIC PUMP TABLETS FOR CONTROLLED DELIVERY OF METOPROLOL TARTRATE
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT

   The aim of the current study was to design a porous osmotic pump-based drug delivery system for controlled release of Metoprolol Tartrate. Based on the principles of an elementary osmotic pump (OP), OP tablets were designed and evaluated with the aim to deliver Metoprolol Tartrate (MT) in a controlled manner. The tablets were prepared by direct compression method. Effects of coating thickness, surface porosity and viscolyzing polymer were studied.  Optimization results indicated that MT release was inversely proportional to the membrane thickness and viscolyzing polymer; however directly proportional to the surface porosity of the membrane, respectively. It was concluded that the osmotic pump tablets could provide more prolonged and controlled MT release that may result in an improved therapeutic efficacy and patient compliance


        

Key words:
Osmotic pump, Controlled release, Metoprolol Tartrate.





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FABRICATION AND IN VITRO EVALUATION OF OSMOTIC PUMP TABLETS FOR CONTROLLED DELIVERY OF METOPROLOL TARTRATE


Shiva Kumar Yellanki 1*, Sambit kumar Deb 1,
Sharada Goranti 1,
R.K. Muthagari2, N.K. Nerella 1, R. Bigala1.

1 Ganga Pharmacy College,
Jawaharlal Nehru Technological University,
Nizamabad, Andra Pradesh, India. 
2 Tirumala College of Pharmacy,
Jawaharlal Nehru Technological University,
Nizamabad, Andra Pradesh, India.


Email:
shiva_kmr1984@yahoo.com
Shiva Kumar Yellanki
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