It is the cache of It is a snapshot of the page. The current page could have changed in the meantime.
Tip: To quickly find your search term on this page, press Ctrl+F or ⌘-F (Mac) and use the find bar.

Silver nanoparticle toxicity in Drosophila: size does matter
skip to content
Dovepress - Open Access to Scientific and Medical Research
View our mobile site


Silver nanoparticle toxicity in Drosophila: size does matter

Original Research

(10275) Total Article Views

Authors: Deborah J Gorth, David M Rand, Thomas J Webster

Published Date February 2011 Volume 2011:6 Pages 343 - 350

Deborah J Gorth1, David M Rand2, Thomas J Webster1
1School of Engineering, 2Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA

Background: Consumer nanotechnology is a growing industry. Silver nanoparticles are the most common nanomaterial added to commercially available products, so understanding the influence that size has on toxicity is integral to the safe use of these new products. This study examined the influence of silver particle size on Drosophila egg development by comparing the toxicity of both nanoscale and conventional-sized silver particles.
Methods: The toxicity assays were conducted by exposing Drosophila eggs to particle concentrations ranging from 10 ppm to 100 ppm of silver. Size, chemistry, and agglomeration of the silver particles were evaluated using transmission electron microscopy, X-ray photoelectron spectroscopy, and dynamic light scattering.
Results: This analysis confirmed individual silver particle sizes in the ranges of 20–30 nm, 100 nm, and 500–1200 nm, with similar chemistry. Dynamic light scattering and transmission electron microscope data also indicated agglomeration in water, with the transmission electron microscopic images showing individual particles in the correct size range, but the dynamic light scattering z-average sizes of the silver nanoparticles were 782 ± 379 nm for the 20–30 nm silver nanoparticles, 693 ± 114 nm for the 100 nm silver nanoparticles, and 508 ± 32 nm for the 500–1200 nm silver particles. Most importantly, here we show significantly more Drosophila egg toxicity when exposed to larger, nonnanometer silver particles. Upon exposure to silver nanoparticles sized 20–30 nm, Drosophila eggs did not exhibit a statistically significant (P < 0.05) decrease in their likelihood to pupate, but eggs exposed to larger silver particles (500–1200 nm) were 91% ± 18% less likely to pupate. Exposure to silver nanoparticles reduced the percentage of pupae able to emerge as adults. At 10 ppm of silver particle exposure, only 57% ± 48% of the pupae exposed to 20–30 nm silver particles became adults, whereas 89% ± 25% of the control group became adults, and 94% ± 52% and 91% ± 19% of the 500–1200 nm and 100 nm group, respectively, reached adulthood.
Conclusion: This research provides evidence that nanoscale silver particles (<100 nm) are less toxic to Drosophila eggs than silver particles of conventional (>100 nm) size.

Keywords: Drosophila, silver, nanoparticle, toxicity


Post to:
Cannotea Citeulike Facebook LinkedIn Twitter


Other articles by Prof. Dr. Thomas J Webster

Anodized 20 nm diameter nanotubular titanium for improved bladder stent applications
Anodizing color coded anodized Ti6Al4V medical devices for increasing bone cell functions
Antimicrobial applications of nanotechnology: methods and literature
Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus
Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
Carbon nanotubes impregnated with subventricular zone neural progenitor cells promotes recovery from stroke
Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood–brain barrier
Cytotoxicity of selenium nanoparticles in rat dermal fibroblasts
Decreased Staphylococcus aureus biofilm formation on nanomodified endotracheal tubes: a dynamic airway model
Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
Decreased cervical cancer cell adhesion on nanotubular titanium for the treatment of cervical cancer
Decreased lung carcinoma cell density on select polymer nanometer surface features for lung replacement therapies
Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium
Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells
Enhanced endothelial cell density on NiTi surfaces with sub-micron to nanometer roughness
Enhanced endothelial cell functions on rosette nanotube-coated titanium vascular stents
Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications
Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
Fructose-enhanced reduction of bacterial growth on nanorough surfaces
Greater fibroblast proliferation on an ultrasonicated ZnO/PVC nanocomposite material
Greater osteoblast and endothelial cell adhesion on nanostructured polyethylene and titanium
Greater osteoblast proliferation on anodized nanotubular titanium upon electrical stimulation
Increased healthy osteoblast to osteosarcoma density ratios on specific PLGA nanopatterns
Influence of nanophase titania topography on bacterial attachment and metabolism
Inhibited growth of Pseudomonas aeruginosa by dextran- and polyacrylic acid-coated ceria nanoparticles
Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications
Mechanisms of greater cardiomyocyte functions on conductive nanoengineered composites for cardiovascular applications
Mechanisms of greater cardiomyocytes functions on conductive nanoengineered composites for cardiovascular applications. [Corrigendum]
Nano rough micron patterned titanium for directing osteoblast morphology and adhesion
Nano-BaSO4: a novel antimicrobial additive to pellethane
Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
Nanostructured magnesium has fewer detrimental effects on osteoblast function
Nanostructured polyurethane-poly-lactic- co-glycolic acid scaffolds increase bladder tissue regeneration: an in vivo study
Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
Reduced adhesion of macrophages on anodized titanium with select nanotube surface features
Reducing infections through nanotechnology and nanoparticles
Selenium nanoparticles inhibit Staphylococcus aureus growth
Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation
Short communication: inhibiting biofilm formation on paper towels through the use of selenium nanoparticles coatings
Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
Spray deposition of live cells throughout the electrospinning process produces nanofibrous three-dimensional tissue scaffolds
The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
The use of superparamagnetic nanoparticles for prosthetic biofilm prevention
Understanding the wetting properties of nanostructured selenium coatings: the role of nanostructured surface roughness and air-pocket formation
Using mathematical models to understand the effect of nanoscale roughness on protein adsorption for improving medical devices

Readers of this article also read: