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��< h t m l > < h e a d > < m e t a H T T P - E Q U I V = " D e s c r i p t i o n " N A M E = " D e s c r i p t i o n " C O N T E N T = " O J H A S i s I n d i a ' s f i r s t , o n l i n e - o n l y , p e e r r e v i e w e d , o p e n a c c e s s , b i o m e d i c a l j o u r n a l ; n o w a r c h i v e d i n C o g p r i n t s " > < m e t a H T T P - E Q U I V = " K e y w o r d s " N A M E = " K e y w o r d s " C O N T E N T = " o n l i n e j o u r n a l , p e e r r e v i e w , c o g p r i n t s , d o a j , o p e n a c c e s s , b i o m e d i c a l , j o u r n a l , h e a l t h , a l l i e d s c i e n c e , o j h a s , m a n g a l o r e , i n d i a , M a r d i K , K a u s h a l V , P r i m a r y T r a n s i t i o n a l C e l l C a r c i n o m a , F a l l o p i a n T u b e " > < s t y l e t y p e = " t e x t / c s s " > < ! - - A : l i n k { t e x t - d e c o r a t i o n : n o n e ; c o l o r : # f f 0 0 0 0 } A : v i s i t e d { t e x t - d e c o r a t i o n : n o n e ; c o l o r : # 0 0 0 0 0 0 } A : h o v e r { t e x t - d e c o r a t i o n : u n d e r l i n e ; c o l o r : # f f 0 0 0 0 } - - > < / s t y l e > < s t y l e t y p e = " t e x t / c s s " > B O D Y { S C R O L L B A R - F A C E - C O L O R : # 4 8 6 3 A 0 ; S C R O L L B A R - H I G H L I G H T - C O L O R : # 1 5 8 9 F F ; S C R O L L B A R - S H A D O W - C O L O R : # 9 9 9 9 f f ; S C R O L L B A R - 3 D L I G H T - C O L O R : # 9 9 9 9 f f ; S C R O L L B A R - A R R O W - C O L O R : # f f f f c e ; S C R O L L B A R - T R A C K - C O L O R : # F F F F F F ; S C R O L L B A R - D A R K S H A D O W - C O L O R : b l a c k } < / s t y l e > < s t y l e t y p e = " t e x t / c s s " > < ! - - . d r o p c a p { f l o a t : l e f t ; c o l o r : # 6 2 6 2 9 C ; f o n t - s i z e : 8 0 p x ; l i n e - h e i g h t : 6 0 p x ; p a d d i n g - t o p : 2 p x ; f o n t - f a m i l y : T i m e s ; } - - > < / s t y l e > < t i t l e > O J H A S : 2 0 1 1 - 4 - 8 . M a r d i K , K a u s h a l V . P r i m a r y T r a n s i t i o n a l C e l l C a r c i n o m a o f t h e F a l l o p i a n T u b e . < / t i t l e > < / h e a d > < b o d y > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " > / / H V M e n u - b y G e r V e r s l u i s ( h t t p : / / w w w . b u r m e e s . n l / ) / / S u b m i t t e d t o D y n a m i c D r i v e ( h t t p : / / w w w . d y n a m i c d r i v e . c o m ) / / V i s i t h t t p : / / w w w . d y n a m i c d r i v e . c o m f o r t h i s s c r i p t a n d m o r e f u n c t i o n G o ( ) { r e t u r n } < / s c r i p t > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " s r c = " . . / i s s u e 1 / e x m p l m e n u _ v a r . j s " > < / s c r i p t > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " s r c = " . . / i s s u e 1 / m e n u _ c o m . j s " > < / s c r i p t > < n o s c r i p t > < p > Y o u r b r o w s e r d o e s n o t s u p p o r t s c r i p t < / n o s c r i p t > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 0 0 % " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 0 0 % " > < a h r e f = " h t t p : / / o j h a s . o r g " > < i m g b o r d e r = " 0 " s r c = " . . / o j h a s l o g o 2 . g i f " w i d t h = " 3 2 9 " h e i g h t = " 8 8 " a l i g n = " l e f t " > < / a > < / t d > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " b g c o l o r = " c r i m s o n " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " b g c o l o r = " c r i m s o n " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 1 0 0 % " > < t r > < t d w i d t h = " 1 2 0 " v a l i g n = " t o p " > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 2 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " a l i g n = " c e n t e r " > < f o n t s i z e = " 1 " f a c e = " V e r d a n a " c o l o r = " # 6 2 6 2 9 C " > < s t r o n g s t y l e = " f o n t - w e i g h t : 4 0 0 " > I S S N 0 9 7 2 - 5 9 9 7 < / s t r o n g > < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " a l i g n = " c e n t e r " > < f o n t s i z e = " 1 " f a c e = " V e r d a n a " c o l o r = " # 6 2 6 2 9 C " > < s t r o n g s t y l e = " f o n t - w e i g h t : 4 0 0 " > P u b l i s h e d Q u a r t e r l y < / s t r o n g > < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " a l i g n = " c e n t e r " > < f o n t s i z e = " 1 " f a c e = " V e r d a n a " c o l o r = " # 6 2 6 2 9 C " > < s t r o n g s t y l e = " f o n t - w e i g h t : 4 0 0 " > M a n g a l o r e , I n d i a < / s t r o n g > < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " a l i g n = " c e n t e r " > < s t r o n g s t y l e = " f o n t - w e i g h t : 4 0 0 " > < f o n t f a c e = " V e r d a n a " s i z e = " 1 " c o l o r = " # 6 2 6 2 9 C " > < a h r e f = " m a i l t o : e d i t o r . o j h a s @ g m a i l . c o m " > e d i t o r . o j h a s @ g m a i l . c o m < / a > < / f o n t > < / s t r o n g > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 8 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 1 4 0 " v a l i g n = " t o p " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 1 0 " v a l i g n = " t o p " > < s t y l e t y p e = " t e x t / c s s " > @ i m p o r t u r l ( h t t p : / / w w w . g o o g l e . c o m / c s e / a p i / b r a n d i n g . c s s ) ; < / s t y l e > < d i v c l a s s = " c s e - b r a n d i n g - b o t t o m " s t y l e = " b a c k g r o u n d - c o l o r : # F F F F F F ; c o l o r : # 0 0 0 0 0 0 " > < d i v c l a s s = " c s e - b r a n d i n g - f o r m " > < f o r m a c t i o n = " h t t p : / / w w w . g o o g l e . c o m / c s e " i d = " c s e - s e a r c h - b o x " t a r g e t = " _ b l a n k " > < d i v > < i n p u t t y p e = " h i d d e n " n a m e = " c x " v a l u e = " p a r t n e r - p u b - 1 9 5 1 4 3 8 3 5 9 2 9 1 1 3 2 : 1 5 9 7 7 0 8 8 3 9 " / > < i n p u t t y p e = " h i d d e n " n a m e = " i e " v a l u e = " U T F - 8 " / > < i n p u t t y p e = " t e x t " n a m e = " q " s i z e = " 1 5 " / > < i n p u t t y p e = " s u b m i t " n a m e = " s a " v a l u e = " S e a r c h " / > < / d i v > < / f o r m > < / d i v > < d i v c l a s s = " c s e - b r a n d i n g - l o g o " > < i m g s r c = " h t t p : / / w w w . g o o g l e . c o m / i m a g e s / p o w e r e d b y _ t r a n s p a r e n t / p o w e r e d b y _ F F F F F F . g i f " a l t = " G o o g l e " w i d t h = " 5 6 " h e i g h t = " 2 0 " / > < / d i v > < d i v c l a s s = " c s e - b r a n d i n g - t e x t " > C u s t o m S e a r c h < / d i v > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 4 0 " v a l i g n = " t o p " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 6 0 1 " > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 4 0 " > < t r > < t d w i d t h = " 9 " v a l i g n = " t o p " > < / t d > < t d w i d t h = " 1 2 1 " v a l i g n = " t o p " > < p a l i g n = " c e n t e r " > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " > < ! - - g o o g l e _ a d _ c l i e n t = " p u b - 1 9 5 1 4 3 8 3 5 9 2 9 1 1 3 2 " ; g o o g l e _ a d _ w i d t h = 1 2 0 ; g o o g l e _ a d _ h e i g h t = 6 0 0 ; g o o g l e _ a d _ f o r m a t = " 1 2 0 x 6 0 0 _ a s " ; g o o g l e _ a d _ c h a n n e l = " " ; g o o g l e _ c o l o r _ b o r d e r = " B 4 D 0 D C " ; g o o g l e _ c o l o r _ b g = " E C F 8 F F " ; g o o g l e _ c o l o r _ l i n k = " 0 0 0 0 C C " ; g o o g l e _ c o l o r _ u r l = " 0 0 8 0 0 0 " ; g o o g l e _ c o l o r _ t e x t = " 6 F 6 F 6 F " ; / / - - > < / s c r i p t > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " s r c = " h t t p : / / p a g e a d 2 . g o o g l e s y n d i c a t i o n . c o m / p a g e a d / s h o w _ a d s . j s " > < / s c r i p t > < / t d > < t d w i d t h = " 1 0 " > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 2 0 " h e i g h t = " 5 " > < / t d > < / t r > < / t a b l e > < / d i v > < / t d > < t d w i d t h = " 5 " v a l i g n = " t o p " > < / t d > < t d v a l i g n = " t o p " > < t a b l e b o r d e r = " 1 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 9 9 C C F F " w i d t h = " 1 0 0 % " > < t r > < t d w i d t h = " 1 0 0 % " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 1 0 0 % " > < t r > < t d w i d t h = " 1 0 0 % " b g c o l o r = " s t e e l b l u e " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # E 8 F 1 F F " > O J H A S V o l . 1 0 , I s s u e 4 : ( O c t - D e c 2 0 1 1 ) < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 3 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 1 " b g c o l o r = " # F 4 0 0 0 0 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # F 4 0 0 0 0 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 4 7 " b g c o l o r = " # F 4 0 0 0 0 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # F 4 0 0 0 0 " h e i g h t = " 2 5 " > < / t d > < t d w i d t h = " 2 " h e i g h t = " 2 5 " b g c o l o r = " # F F E 3 E 3 " > < / t d > < t d w i d t h = " 2 4 7 " h e i g h t = " 2 5 " b g c o l o r = " # F F E 3 E 3 " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # F 4 0 0 0 0 " > C a s e R e p o r t < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < s t r o n g > < f o n t f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 A 0 " > P r i m a r y T r a n s i t i o n a l C e l l C a r c i n o m a o f t h e F a l l o p i a n T u b e < / f o n t > < / s t r o n g > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 2 0 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 1 0 0 % " > < t r > < t d > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 4 7 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 2 5 " > < / t d > < t d w i d t h = " 2 " h e i g h t = " 2 5 " b g c o l o r = " # D 7 F B E 1 " > < / t d > < t d w i d t h = " 2 4 7 " h e i g h t = " 2 5 " b g c o l o r = " # D 7 F B E 1 " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 4 3 7 1 3 " > A u t h o r s < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > < b > K a v i t a M a r d i , < / b > A s s o c i a t e P r o f e s s o r , < b r > < b > V i j a y K a u s h a l , < / b > P r o f e s s o r & a m p ; H e a d , < B R > < B > D e p t . o f P a t h o l o g y , I n d i r a G a n d h i M e d i c a l C o l l e g e , S h i m l a . < / B > < / f o n t > < / t d > < t d w i d t h = " 2 0 " > & n b s p ; < / t d > < t d w i d t h = " 3 0 0 " r o w s p a n = " 3 " v a l i g n = " t o p " > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 3 0 0 " > < t r > < t d w i d t h = " 3 0 0 " > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " > < ! - - g o o g l e _ a d _ c l i e n t = " p u b - 1 9 5 1 4 3 8 3 5 9 2 9 1 1 3 2 " ; g o o g l e _ a d _ w i d t h = 3 0 0 ; g o o g l e _ a d _ h e i g h t = 2 5 0 ; g o o g l e _ a d _ f o r m a t = " 3 0 0 x 2 5 0 _ a s " ; g o o g l e _ a d _ t y p e = " t e x t _ i m a g e " ; / / 2 0 0 7 - 0 1 - 2 5 : O n l i n e J o u r n a l g o o g l e _ a d _ c h a n n e l = " 0 1 5 9 5 9 2 9 5 3 " ; / / - - > < / s c r i p t > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " s r c = " h t t p : / / p a g e a d 2 . g o o g l e s y n d i c a t i o n . c o m / p a g e a d / s h o w _ a d s . j s " > < / s c r i p t > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < t r > < t d > & n b s p ; < / t d > < t d w i d t h = " 2 0 " > & n b s p ; < / t d > < / t r > < t r > < t d > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 4 7 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 0 4 3 7 1 3 " h e i g h t = " 1 2 " > < / t d > < t d w i d t h = " 2 " h e i g h t = " 1 2 " b g c o l o r = " # D 7 F B E 1 " > < / t d > < t d w i d t h = " 2 4 7 " h e i g h t = " 1 2 " b g c o l o r = " # D 7 F B E 1 " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 4 3 7 1 3 " > A d d r e s s f o r C o r r e s p o n d e n c e < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > < b > D r . K a v i t a M a r d i , < / b > < b r > 1 2 - A , T y p e V Q u a r t e r s , < b r > G A D C o l o n y , K a s u m p t i , < b r > S h i m l a , H i m a c h a l P r a d e s h , I n d i a . < / f o n t > < b r > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " > < f o n t c o l o r = " # 0 0 0 0 8 0 " > < b > E - m a i l : < / b > < / f o n t > < a h r e f = " m a i l t o : k a v i t a m a r d i @ y a h o o . c o . i n " > k a v i t a m a r d i @ y a h o o . c o . i n < / a > < / f o n t > < / t d > < t d w i d t h = " 2 0 " > & n b s p ; < / t d > < / t r > < / t a b l e > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 2 0 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 4 7 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 2 " > < / t d > < t d w i d t h = " 2 " h e i g h t = " 1 2 " b g c o l o r = " # E B E B F A " > < / t d > < t d w i d t h = " 2 4 7 " h e i g h t = " 1 2 " b g c o l o r = " # E B E B F A " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 2 D 3 0 B 7 " > C i t a t i o n < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < p a l i g n = " j u s t i f y " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > M a r d i K , K a u s h a l V . P r i m a r y T r a n s i t i o n a l C e l l C a r c i n o m a o f t h e F a l l o p i a n T u b e . < i > O n l i n e J H e a l t h A l l i e d S c s . < / i > 2 0 1 1 ; 1 0 ( 4 ) : 8 < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " b g c o l o r = " s t e e l b l u e " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 2 0 " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 1 0 0 % " > < t r > < t d w i d t h = " 5 0 % " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 1 0 0 % " > < t r > < t d w i d t h = " 1 0 0 % " > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 4 7 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 2 " > < / t d > < t d w i d t h = " 2 " h e i g h t = " 1 2 " b g c o l o r = " # E B E B F A " > < / t d > < t d w i d t h = " 2 4 7 " h e i g h t = " 1 2 " b g c o l o r = " # E B E B F A " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 2 D 3 0 B 7 " > U R L < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 3 3 9 9 " > < a t a r g e t = " _ b l a n k " h r e f = " h t t p : / / w w w . o j h a s . o r g / i s s u e 4 0 / 2 0 1 1 - 4 - 8 . h t m " > h t t p : / / w w w . o j h a s . o r g / i s s u e 4 0 / 2 0 1 1 - 4 - 8 . h t m < / a > < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 2 4 7 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # 2 D 3 0 B 7 " h e i g h t = " 1 2 " > < / t d > < t d w i d t h = " 2 " h e i g h t = " 1 2 " b g c o l o r = " # E B E B F A " > < / t d > < t d w i d t h = " 2 4 7 " h e i g h t = " 1 2 " b g c o l o r = " # E B E B F A " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 2 D 3 0 B 7 " > O p e n A c c e s s A r c h i v e s < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 3 3 9 9 " > < a h r e f = " h t t p : / / c o g p r i n t s . o r g / v i e w / s u b j e c t s / O J H A S . h t m l " > h t t p : / / c o g p r i n t s . o r g / v i e w / s u b j e c t s / O J H A S . h t m l < / a > < / f o n t > < B R > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 3 3 9 9 " > < a t a r g e t = " _ b l a n k " h r e f = " h t t p : / / o p e n m e d . n i c . i n / v i e w / s u b j e c t s / o j h a s . h t m l " > h t t p : / / o p e n m e d . n i c . i n / v i e w / s u b j e c t s / o j h a s . h t m l < / a > < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > & n b s p ; < / t d > < / t r > < / t a b l e > < / t d > < t d w i d t h = " 2 5 % " v a l i g n = " t o p " > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 1 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 0 0 0 0 F F " w i d t h = " 2 5 0 " > < t r > < t d w i d t h = " 2 5 0 " b g c o l o r = " # E 8 F B F D " > < p a l i g n = " c e n t e r " > < a r e l = " l i c e n s e " h r e f = " h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y - n d / 2 . 5 / i n / " > < i m g a l t = " C r e a t i v e C o m m o n s L i c e n s e " s t y l e = " b o r d e r - w i d t h : 0 " s r c = " h t t p : / / i . c r e a t i v e c o m m o n s . o r g / l / b y - n d / 2 . 5 / i n / 8 8 x 3 1 . p n g " w i d t h = " 8 8 " h e i g h t = " 3 1 " / > < / a > < b r / > T h i s w o r k i s l i c e n s e d u n d e r a < a r e l = " l i c e n s e " h r e f = " h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y - n d / 2 . 5 / i n / " > C r e a t i v e C o m m o n s A t t r i b u t i o n - N o D e r i v a t i v e W o r k s 2 . 5 I n d i a L i c e n s e < / a > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < t d w i d t h = " 2 5 % " v a l i g n = " t o p " > < d i v a l i g n = " r i g h t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 1 3 1 " > < t r > < t d w i d t h = " 1 3 1 " b g c o l o r = " s t e e l b l u e " c o l s p a n = " 5 " > < p a l i g n = " c e n t e r " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # F F F F F F " > T h i s A r t i c l e < / f o n t > < / b > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " s t e e l b l u e " > < / t d > < t d w i d t h = " 4 3 " > < a t a r g e t = " _ b l a n k " h r e f = " 2 0 1 1 - 4 - 8 . p d f " > < i m g b o r d e r = " 0 " s r c = " . . / i s s u e 1 4 / p d f . g i f " w i d t h = " 4 2 " h e i g h t = " 4 8 " > < / a > < / t d > < t d w i d t h = " 4 3 " > < a t a r g e t = " _ b l a n k " h r e f = " h t t p : / / c o g p r i n t s . o r g / 8 8 5 8 / 1 / " > < i m g b o r d e r = " 0 " s r c = " . . / i s s u e 1 4 / c o g p r i . g i f " w i d t h = " 4 2 " h e i g h t = " 4 8 " > < / a > < / t d > < t d w i d t h = " 4 3 " > < a t a r g e t = " _ b l a n k " h r e f = " h t t p : / / o p e n m e d . n i c . i n / 3 8 5 9 / " > < i m g b o r d e r = " 0 " s r c = " . . / i s s u e 1 4 / o p m e d . g i f " w i d t h = " 4 2 " h e i g h t = " 4 8 " > < / t d > < t d w i d t h = " 1 " b g c o l o r = " s t e e l b l u e " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " s t e e l b l u e " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 4 3 " b g c o l o r = " s t e e l b l u e " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 4 3 " b g c o l o r = " s t e e l b l u e " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 4 3 " b g c o l o r = " s t e e l b l u e " h e i g h t = " 1 " > < / t d > < t d w i d t h = " 1 " b g c o l o r = " s t e e l b l u e " h e i g h t = " 1 " > < / t d > < / t r > < / t a b l e > < / d i v > < / t d > < / t r > < / t a b l e > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " b g c o l o r = " s t e e l b l u e " h e i g h t = " 1 5 " > < f o n t f a c e = " V e r d a n a " s i z e = " 1 " c o l o r = " # E 8 F 1 F F " > S u b m i t t e d : D e c 5 , 2 0 1 1 ; A c c e p t e d : J a n 5 , 2 0 1 2 ; P u b l i s h e d : J a n 1 5 , 2 0 1 2 < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " b g c o l o r = " # D C 1 4 3 C " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 5 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 4 6 8 " > < t r > < t d w i d t h = " 4 6 8 " > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " > < ! - - g o o g l e _ a d _ c l i e n t = " p u b - 1 9 5 1 4 3 8 3 5 9 2 9 1 1 3 2 " ; g o o g l e _ a d _ w i d t h = 4 6 8 ; g o o g l e _ a d _ h e i g h t = 6 0 ; g o o g l e _ a d _ f o r m a t = " 4 6 8 x 6 0 _ a s " ; g o o g l e _ a d _ t y p e = " t e x t _ i m a g e " ; g o o g l e _ a d _ c h a n n e l = " " ; g o o g l e _ c o l o r _ b o r d e r = " 3 3 6 6 9 9 " ; g o o g l e _ c o l o r _ b g = " F F F F F F " ; g o o g l e _ c o l o r _ l i n k = " 0 0 0 0 F F " ; g o o g l e _ c o l o r _ u r l = " 0 0 8 0 0 0 " ; g o o g l e _ c o l o r _ t e x t = " 0 0 0 0 0 0 " ; / / - - > < / s c r i p t > & n b s p ; < s c r i p t t y p e = " t e x t / j a v a s c r i p t " s r c = " h t t p : / / p a g e a d 2 . g o o g l e s y n d i c a t i o n . c o m / p a g e a d / s h o w _ a d s . j s " > < / s c r i p t > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 5 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " b g c o l o r = " # D C 1 4 3 C " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 2 0 " > < / t d > < / t r > < / t a b l e > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 0 0 % " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 0 " b g c o l o r = " # F D 7 E 0 0 " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # F F F F F F " > < b > A b s t r a c t : < / b > < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 7 0 " b g c o l o r = " # F F E F D F " > < p a l i g n = " j u s t i f y " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > P r i m a r y c a r c i n o m a o f t h e f a l l o p i a n t u b e i s a r a r e e n t i t y t h a t a c c o u n t s f o r 0 . 2 - 0 . 5 % o f a l l g y n e c o l o g i c m a l i g n a n c i e s , a n d m o s t a r e d i s c o v e r e d d u r i n g o r a f t e r s u r g e r y . P r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a o f t h e f a l l o p i a n t u b e i s a n e x t r e m e l y r a r e t u m o r t h a t i s r e p o r t e d o n l y o c c a s i o n a l l y i n t h e w o r l d w i d e l i t e r a t u r e . A s p r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a ( T C C ) o f t h e f a l l o p i a n t u b e i s s o r a r e , t h e c l i n i c o p a t h o l o g i c c h a r a c t e r i s t i c s a r e a s y e t u n k n o w n . T h e a u t h o r s r e c e n t l y e x p e r i e n c e d a c a s e o f p r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a a r i s i n g i n t h e l e f t f a l l o p i a n t u b e a n d t h u s r e p o r t t h e c l i n i c a l f e a t u r e s , m a n a g e m e n t , a n d a l s o a r e v i e w o f t h e p a s t p e r t i n e n t l i t e r a t u r e . A 5 2 y e a r s o l d w o m a n p r e s e n t i n g w i t h l o w e r a b d o m i n a l p a i n w a s f o u n d t o h a v e a l e f t a d n e x a l m a s s . E x p l o r a t o r y l a p a r o t o m y r e v e a l e d a m a s s a r i s i n g f r o m t h e l e f t f a l l o p i a n t u b e w i t h t h e h i s t o l o g i c f e a t u r e s o f t r a n s i t i o n a l c e l l c a r c i n o m a . � < / f o n t > < b r > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > < b > K e y W o r d s : < / b > T r a n s i t i o n a l c e l l c a r c i n o m a ; F a l l o p i a n t u b e . < / f o n t > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 0 " > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 5 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # E C 0 0 E C " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # F F E 6 F F " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 A 0 " > < b > I n t r o d u c t i o n < / b > < / f o n t > < / t d > < / t r > < / t a b l e > < / d i v > < p a l i g n = " j u s t i f y " > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > T r a n s i t i o n a l c e l l c a r c i n o m a a r i s i n g f r o m t h e f a l l o p i a n t u b e i s a n e x c e e d i n g l y r a r e e n t i t y t h a t a c c o u n t s f o r 0 . 2 - 0 . 5 % o f a l l g y n e c o l o g i c m a l i g n a n c i e s . < s u p > 1 - 3 < / s u p > W e h e r e i n r e p o r t o n e s u c h r a r e o c c u r r e n c e i n a 5 2 y e a r s o l d f e m a l e . < / f o n t > < / p > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 5 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # E C 0 0 E C " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # F F E 6 F F " > < b > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 A 0 " > C a s e R e p o r t < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / d i v > < p a l i g n = " j u s t i f y " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > A 5 2 y e a r s o l d l a d y p r e s e n t e d w i t h i n t e r m i t t e n t c o l i c k y l o w e r a b d o m i n a l p a i n o f 1 - m o n t h d u r a t i o n . S h e h a d A t t a i n e d m e n o p a u s e 5 y e a r s b a c k . H e r b l a d d e r a n d b o w e l h a b i t s w e r e n o r m a l . O n e x a m i n a t i o n , s h e w a s o f a v e r a g e b u i l d w i t h g o o d p e r f o r m a n c e s t a t u s . H e r v i t a l s w e r e s t a b l e , w i t h n o p a l l o r , e d e m a o r l y m p h a d e n o p a t h y . O n v a g i n a l e x a m i n a t i o n , a l e f t a d n e x a l m a s s o f a b o u t 3 c m d i a m e t e r w a s f e l t . H o w e v e r , p e r r e c t a l e x a m i n a t i o n d i d n o t r e v e a l a n y m a s s i n t h e p o u c h o f D o u g l a s ( P O D ) . < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > P a t i e n t w a s e v a l u a t e d w i t h r o u t i n e b l o o d i n v e s t i g a t i o n s , t u m o r m a r k e r s a n d i m a g i n g , i n c l u d i n g u l t r a s o u n d a n d a C T s c a n o f t h e a b d o m e n a n d p e l v i s . T h u s , w i t h a p r o v i s i o n a l d i a g n o s i s o f o v a r i a n m a l i g n a n c y , t h e p a t i e n t u n d e r w e n t a s t a g i n g l a p a r o t o m y . P e r - o p e r a t i v e l y , t h e r e w a s 3 x 3 c m s i z e d , w e l l c i r c u m s c r i b e d & n b s p ; m a s s a r i s i n g f r o m t h e l e f t f a l l o p i a n t u b e . C u t s e c t i o n o f t h e m a s s w a s s o i l d , g r e y w h i t e w i t h n e c r o t i c a n d h e m o r r h a g i c a r e a s . B o t h t h e o v a r i e s , o n g r o s s e x a m i n a t i o n , a p p e a r e d a p p a r e n t l y n o r m a l ( F i g u r e 1 ) . N o o b v i o u s d e p o s i t s w e r e f o u n d o n t h e P O D , a b d o m i n a l o r d i a p h r a g m a t i c p e r i t o n e a l s u r f a c e s . L i v e r a n d o m e n t u m a p p e a r e d f r e e o f d i s e a s e . N o s i g n i f i c a n t l y e n l a r g e d p e l v i c o r p a r a - a o r t i c n o d e s w e r e p r e s e n t . H i s t o l o g i c a l l y , t h e t u m o r s u r r o u n d e d t h e l u m e n o f t h e l e f t f a l l o p i a n t u b e a n d w a s c o m p o s e d o f c e l l s w i t h " c o f f e e - b e a n " - l i k e n u c l e i a r r a n g e d i n s o l i d n e s t s w i t h o u t k e r a t i n i z a t i o n . F o c a l l y t h e t u m o r c e l l s a r e a r r a n g e d a r o u n d p a p i l l a e w i t h f i n e f i b r o v a s c u l a r c o r e s ( F i g u r e 2 ) . I n a d d i t i o n , t h e r e w e r e a r e a s o f n e c r o s i s i n t h e c e n t e r o f s h e e t s o f t u m o r c e l l s . P A S a n d M u c i c a r m i n e s t a i n s w e r e n e g a t i v e . N o a b n o r m a l i t i e s w e r e f o u n d i n t h e r i g h t t u b e , o v a r i e s , o r u t e r u s . T h e d i a g n o s i s o f p r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a o f t h e f a l l o p i a n t u b e w a s r e n d e r e d . < / f o n t > < / p > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 8 0 0 " > < t r > < t d > < i m g b o r d e r = " 0 " s r c = " 2 0 1 1 - 4 - 8 - 1 . g i f " w i d t h = " 4 0 0 " h e i g h t = " 3 0 0 " > < / t d > < t d > < i m g b o r d e r = " 0 " s r c = " 2 0 1 1 - 4 - 8 - 2 . g i f " w i d t h = " 4 0 0 " h e i g h t = " 3 0 0 " > < / t d > < / t r > < t r > < t d a l i g n = " c e n t e r " v a l i g n = " t o p " > < b > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > F i g u r e 1 : G r o s s p h o t o g r a p h r e v e a l i n g c u t s e c t i o n o f t h e g r o w t h a r i s i n g f r o m t h e l e f t f a l l o p i a n t u b e < / f o n t > < / b > < / t d > < t d a l i g n = " c e n t e r " v a l i g n = " t o p " > < b > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > F i g u r e 2 : P h o t o m i c r o g r a p h r e v e a l i n g p a p i l l a e w i t h f i b r o v a s c u l a r c o r e s l i n e d b y m a l i g n a n t t r a n s i t i o n a l e p i t h e l i u m . ( H & a m p ; E , 2 0 x ) < / f o n t > < / b > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 5 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # E C 0 0 E C " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # F F E 6 F F " > < f o n t s i z e = " 2 " c o l o r = " # 0 0 0 0 A 0 " f a c e = " V e r d a n a " > < b > D i s c u s s i o n < / b > < / f o n t > < / t d > < / t r > < / t a b l e > < / d i v > < p a l i g n = " j u s t i f y " > < f o n t f a c e = " V e r d a n a " s i z e = " 2 " c o l o r = " # 0 0 0 0 8 0 " > P r i m a r y F a l l o p i a n t u b e c a r c i n o m a ( P F T C ) , f i r s t d e s c r i b e d b y R e n a u d i n 1 8 4 7 , i s t h e l e a s t c o m m o n g y n e c o l o g i c a l m a l i g n a n c y e n c o u n t e r e d i n p r a c t i c e . T h e s e t u m o r s c o n s t i t u t e 0 . 2 0 . 5 % o f p r i m a r y f e m a l e g e n i t a l m a l i g n a n c i e s . < s u p > 1 - 3 < / s u p > I n p r i m a r y t u b a l m a l i g n a n c y , t h e u t e r u s a n d o v a r i e s s h o u l d a p p e a r & n b s p ; n o r m a l o n g r o s s e x a m i n a t i o n . T h e f o c i o f m a l i g n a n c i e s i n t h e s e o r g a n s , i f p r e s e n t s h o u l d h a v e t h e a p p e a r a n c e o f m e t a s t a s i s o r a s i n d e p e n d e n t p r i m a r i e s b y v i r t u e o f t h e i r s i z e a n d d i s t r i b u t i o n . < s u p > 4 < / s u p > < b > < / b > H i s t o l o g i c a l l y m o s t o f t h e s e a r e a d e n o c a r c i n o m a s . P r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a ( T C C ) a c c o u n t s f o r a b o u t 1 0 % o f p r i m a r y t u b a l c a r c i n o m a s . < s u p > 1 < / s u p > T h u s T r a n s i t i o n a l c e l l c a r c i n o m a o f t h e f a l l o p i a n t u b e i s a v e r y r a r e h i s t o l o g i c a l v a r i a n t , w i t h o n l y a r o u n d 2 0 c a s e s h a v i n g b e e n r e p o r t e d w o r l d w i d e s o f a r . < s u p > 2 , 3 < / s u p > < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t c o l o r = " # 0 0 0 0 8 0 " s i z e = " 2 " f a c e = " V e r d a n a " > P F T C i s m o r e c o m m o n l y s e e n i n p o s t m e n o p a u s a l w o m e n , b u t i t i s n o t c l e a r w h e t h e r t h e s a m e i s t r u e a b o u t p r i m a r y t r a n s i t i o n a l c a r c i n o m a . . P a t i e n t s w i t h P F T C a p p e a r t o h a v e a s h o r t e r h i s t o r y o f s y m p t o m s c o m p a r e d t o t h o s e w i t h e p i t h e l i a l o v a r i a n c a n c e r ( P E O C ) . A b o u t 5 0 % t o 6 0 % o f p a t i e n t s p r e s e n t w i t h v a g i n a l b l e e d i n g o r s p o t t i n g , a b d o m i n a l a n d / o r p e l v i c m a s s ; a n d 3 0 % t o 4 0 % o f p a t i e n t s p r e s e n t w i t h c o l i c k y o r d u l l a b d o m i n a l p a i n . < s u p > 5 < / s u p > L a t z k e t r i a d o f s y m p t o m s , c o n s i s t i n g o f i n t e r m i t t e n t p r o f u s e s e r o s a n g u i n o u s v a g i n a l d i s c h a r g e , a b d o m i n a l a n d / o r p e l v i c p a i n , i s r e p o r t e d i n 1 5 % o f c a s e s . G r o s s l y , t h e t u b a l l u m e n i s u s u a l l y f i l l e d a n d d i l a t e d b y p a p i l l a r y o r s o l i d a n d n e c r o t i c t u m o r . T h e m o r p h o l o g y o f t r a n s i t i o n a l c a r c i n o m a i s s i m i l a r t o t h a t o f t u m o r s o f t h e u r o t h e l i u m . < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " > < f o n t c o l o r = " # 0 0 0 0 8 0 " > T h e r e i s a n e w l y r e c o g n i z e d e n t i t y k n o w n a s p a r a f a l l o p i a n t u b e c a r c i n o m a , w h e r e t h e t u m o r i s c l o s e l y a t t a c h e d t o t h e e x t r a l u m i n a l p o r t i o n o f t h e t u b e . I t i s p r e s u m e d t o a r i s e f r o m W a l t h a r d ' s r e s t , p a r a t u b a l c y s t o r d i r e c t l y f r o m t h e t u b a l s e r o s a . < / f o n t > < s u p > < f o n t c o l o r = " # 0 0 0 0 8 0 " > 6 < / f o n t > < / s u p > < f o n t c o l o r = " # 0 0 0 0 8 0 " > H e n c e i t i s i m p o r t a n t t o d i s t i n g u i s h P T C C o f f a l l o p i a n t u b e f r o m p a r a f a l l o p i a n t u b e t r a n s i t i o n a l c e l l c a r c i n o m a t o i d e n t i f y a n y d i f f e r e n c e i n c l i n i c a l c h a r a c t e r i s t i c s . < / f o n t > < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t c o l o r = " # 0 0 0 0 8 0 " s i z e = " 2 " f a c e = " V e r d a n a " > B e t w e e n 0 % a n d 2 3 % o f c a s e s o f P F T C m a y h a v e a b n o r m a l c e r v i c a l c y t o l o g y s u g g e s t i v e o f a d e n o c a r c i n o m a . < s u p > 5 < / s u p > & n b s p ; P a p s m e a r w a s n e g a t i v e i n t h e p r e s e n t c a s e a s w e l l . T h e r e i s a n i s o l a t e d c a s e r e p o r t o f t r a n s i t i o n a l c e l l c a r c i n o m a o f t h e f a l l o p i a n t u b e d i a g n o s e d a f t e r a t o t a l a b d o m i n a l h y s t e r e c t o m y w i t h s a l p i n g o - o o p h o r e c t o m y d o n e f o r r e p e a t e d P a p s m e a r r e p o r t s s u g g e s t i v e o f s q u a m o u s c e l l c a r c i n o m a . < s u p > 2 < / s u p > < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t c o l o r = " # 0 0 0 0 8 0 " s i z e = " 2 " f a c e = " V e r d a n a " > T h e r e p o r t e d r a t e o f p r e o p e r a t i v e d i a g n o s i s i n f a l l o p i a n t u b e c a r c i n o m a i s l o w . B a e k e l a n d t e t a l , h a v e r e p o r t e d a p r e o p e r a t i v e d i a g n o s i s r a t e o f 2 % . < s u p > 7 < / s u p > B o t h t h e U S G a n d t h e C T s c a n c o u l d n o t s u g g e s t a d i a g n o s i s o f P F T C i n t h i s c a s e b e c a u s e t h e o v a r y o n t h e l e f t s i d e w a s n o t s e e n s e p a r a t e l y f r o m t h e a d n e x a l m a s s . H o w e v e r , m a r k e d l y e l e v a t e d C A - 1 2 5 l e v e l w a s s t r o n g l y s u g g e s t i v e o f m a l i g n a n c y i n t h e p r e s e n t c a s e . T h e p r e t r e a t m e n t C A - 1 2 5 l e v e l i s a n i n d e p e n d e n t p r o g n o s t i c f a c t o r o f d i s e a s e - f r e e s u r v i v a l a n d o v e r a l l s u r v i v a l & n b s p ; i n p a t i e n t s w i t h P F T C . C A - 1 2 5 i s a l s o f o u n d t o b e a g o o d m a r k e r f o r p o s t - t r e a t m e n t f o l l o w - u p , s i m i l a r t o o v a r i a n c a r c i n o m a . < s u p > 5 < / s u p > < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t c o l o r = " # 0 0 0 0 8 0 " s i z e = " 2 " f a c e = " V e r d a n a " > S u r g e r y i s t h e t r e a t m e n t o f c h o i c e , a s i n c a s e s o f o v a r i a n t u m o r s . A s t a g i n g l a p a r o t o m y t h r o u g h a g e n e r o u s m i d l i n e v e r t i c a l i n c i s i o n i s r e c o m m e n d e d , a s i n c a s e s o f o v a r i a n c a n c e r . S t u d i e s s u g g e s t t h a t p a t i e n t s w i t h P F T C h a v e h i g h e r r a t e s o f r e t r o p e r i t o n e a l a n d d i s t a n t n o d a l m e t a s t a s e s t h a n t h o s e w i t h e p i t h e l i a l o v a r i a n c a n c e r . < s u p > 8 < / s u p > H e n c e a s y s t e m a t i c p e l v i c a n d p a r a - a o r t i c l y m p h a d e n e c t o m y i s p r e f e r r e d t o s e l e c t i v e l y m p h n o d e s a m p l i n g . < / f o n t > < / p > < p a l i g n = " j u s t i f y " > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > P a t i e n t s w i t h s t a g e I d i s e a s e w i t h o u t r i s k f a c t o r s l i k e i n v o l v e m e n t o f t h e m u s c u l a r i s l a y e r w e r e r e p o r t e d t o h a v e 1 0 0 % 5 - y e a r s u r v i v a l a n d n e e d n o t b e t r e a t e d w i t h a d j u v a n t c h e m o t h e r a p y . I n c o n t r a s t , s t a g e I w i t h i n v a s i o n o f t h e m u s c u l a r i s l a y e r o r t u m o r i n t h e f i m b r i a a n d h i g h e r s t a g e s s h o u l d r e c e i v e a d j u v a n t c h e m o t h e r a p y . < s u p > 8 , 9 < / s u p > A d j u v a n t c h e m o t h e r a p y w i t h a c o m b i n a t i o n o f c a r b o p l a t i n a n d p a c l i t a x e l , w h i c h i s t h e g o l d s t a n d a r d o f c h e m o t h e r a p y i n e p i t h e l i a l o v a r i a n c a n c e r , i s n o w i n c r e a s i n g l y b e i n g u s e d i n P F T C . < s u p > 1 0 < / s u p > O u r l i t e r a t u r e s e a r c h d i d n o t r e v e a l a n y r e p o r t o f c o n s e r v a t i v e m a n a g e m e n t i n t h e f o r m o f u n i l a t e r a l s a l p i n g e c t o m y o r s a l p i n g o - o o p h o r e c t o m y f o r e a r l y - s t a g e P T C C o f t h e f a l l o p i a n t u b e . & n b s p ; < b r > U e h i r a e t a < i > , < / i > i n a s t u d y c o m p a r i n g t r a n s i t i o n a l c e l l ( T C ) - p r e d o m i n a n t P F T C w i t h n o n - T C - p r e d o m i n a n t P F T C f o u n d t h a t T C - p r e d o m i n a n t t u m o r s t e n d e d t o r e l a p s e l a t e r ( m e a n , 3 1 . 2 m o n t h s a f t e r d i a g n o s i s ) t h a n n o n - T C - p r e d o m i n a n t t u m o r s ( m e a n , 1 4 . 4 m o n t h s a f t e r d i a g n o s i s ) , r e s u l t i n g i n a s i g n i f i c a n t d i f f e r e n c e i n t h e 2 - y e a r d i s e a s e - f r e e s u r v i v a l r a t e . H e n c e h e c o n c l u d e d t h a t T C p a t t e r n a n d n o n - T C p a t t e r n a r e c o n s i d e r e d t o b e w o r t h y o f d i s t i n c t i o n i n P F T C . < s u p > 1 1 < / s u p > < / p > < d i v a l i g n = " l e f t " > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 5 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " > < t r > < t d w i d t h = " 1 " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " > & n b s p ; < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # E C 0 0 E C " > < / t d > < / t r > < t r > < t d w i d t h = " 1 " b g c o l o r = " # E C 0 0 E C " > < / t d > < t d w i d t h = " 2 " > < / t d > < t d w i d t h = " 1 4 7 " b g c o l o r = " # F F E 6 F F " > < f o n t s i z e = " 2 " c o l o r = " # 0 0 0 0 A 0 " f a c e = " V e r d a n a " > < b > R e f e r e n c e s < / b > < / f o n t > < / t d > < / t r > < / t a b l e > < / d i v > < o l s t y l e = " c o l o r : # 0 0 0 0 8 0 ; f o n t - s i z e : 1 0 p t ; f o n t - f a m i l y : V e r d a n a " > < l i > < p a l i g n = " j u s t i f y " > K i m J W , C h o E M , K i m Y T , H a n J H : A c a s e o f p r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a o f t h e f a l l o p i a n t u b e . < i > J O b s t e t G y n a e c o l R e s < / i > 1 9 9 9 ; 2 5 < b > : < / b > 3 2 1 - 3 2 6 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > G u p t a N , S r i n i v a s a n R , N i j h a w a n R , D h a l i w a l L K . P r i m a r y f a l l o p i a n t u b e c a r c i n o m a w i t h e x f o l i a t i o n o f m a l i g n a n t c e l l s i n c e r v i c a l p a p s m e a r . < i > C y t o j o u r n a l < / i > 2 0 0 5 ; 2 : 2 0 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > P a r k J S , C h a n g K H , B y u n J G , L e e J P , R y u H S , H a n J H . A c a s e o f p r i m a r y t r a n s i t i o n a l c e l l c a r c i n o m a o f t h e f a l l o p i a n t u b e . & n b s p ; < i > K o r e a n J O b s t e t G y n e c o l < / i > 2 0 0 5 ; 4 8 : 1 3 5 1 - 1 3 5 7 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > R o s e P G , P i v e r M S , T s u k a d a Y . F a l l o p i a n t u b e c a n c e r : T h e R o s e w a l l p a r k e x p e r i e n c e . < i > C a n c e r < / i > 1 9 9 0 ; 6 6 : 2 6 6 1 - 2 6 6 7 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > P e c t a s i d e s D , P e c t a s i d e s E , E c o n o m o p o u l o s T . F a l l o p i a n t u b e c a r c i n o m a : A r e v i e w . < i > O n c o l o g i s t < / i > 2 0 0 6 ; 1 1 : 9 0 2 - 9 1 2 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > P a n e r G P , G o n z a l e z M , A l - M a s r i H , S m i t h D M , H u s a i n A N . P a r a f a l l o p i a n t u b e t r a n s i t i o n a l c e l l c a r c i n o m a . < i > G y n e c o l O n c o l < / i > 2 0 0 2 ; 8 6 : 3 7 9 - 3 8 3 . & n b s p ; & n b s p ; < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > B a e k e l a n d t M , K o c k x M , W e s l i n g F , G e r r i s J . P r i m a r y a d e n o c a r c i n o m a o f t h e f a l l o p i a n t u b e . R e v i e w o f l i t e r a t u r e . < i > I n t J G y n e c o l C a n c e r < / i > 1 9 9 3 ; 3 : 6 5 - 3 7 1 . & n b s p ; & n b s p ; & n b s p ; < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > M a x s o n W Z , S t e h m a n F B , U l b r i g h t T M , S u t t o n G P , E h r l i c h C E . P r i m a r y c a r c i n o m a o f t h e f a l l o p i a n t u b e : E v i d e n c e f o r a c t i v i t y o f c i s p l a t i n c o m b i n a t i o n t h e r a p y . < i > G y n e c o l O n c o l < / i > 1 9 8 7 ; 2 6 : 3 0 5 - 3 1 3 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > A l v a r a d o - C a b r e r o I , Y o u n g R H , V a m v a k a s E C , S c u l l y R E . C a r c i n o m a o f t h e f a l l o p i a n t u b e : A c l i n i c o p a t h o l o g i c a l s t u d y o f 1 0 5 c a s e s w i t h o b s e r v a t i o n s o n s t a g i n g a n d p r o g n o s t i c f a c t o r s . < i > G y n e c o l O n c o l < / i > 1 9 9 9 ; 7 2 : 3 6 7 - 3 7 9 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > G e m i g n a n i M L , H e n s l e y M L , C o h e n R , V e n k a t r a m a n E , S a i g o P E , B a r a k a t R R . P a c l i t a x e l - b a s e d c h e m o t h e r a p y i n c a r c i n o m a o f t h e f a l l o p i a n t u b e . < i > G y n e c o l O n c o l < / i > 2 0 0 1 ; 8 0 : 1 6 - 2 0 . < / f o n t > < / l i > < l i > < f o n t s i z e = " 2 " f a c e = " V e r d a n a " c o l o r = " # 0 0 0 0 8 0 " > U e h i r a K , H a s h i m o t o H , T s u n e y o s h i M , E n j o j i M . T r a n s i t i o n a l c e l l c a r c i n o m a p a t t e r n i n p r i m a r y c a r c i n o m a o f t h e f a l l o p i a n t u b e . < i > C a n c e r < / i > 1 9 9 3 ; 7 2 : 2 4 4 7 - 2 4 5 6 . & n b s p ; < / l i > < / o l > < f o n t s i z e = " 3 " f a c e = " T i m e s N e w R o m a n " > < / o l > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < / t r > < / t a b l e > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " b g c o l o r = " c r i m s o n " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 " b g c o l o r = " c r i m s o n " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " s t y l e = " b o r d e r - c o l l a p s e : c o l l a p s e " b o r d e r c o l o r = " # 1 1 1 1 1 1 " w i d t h = " 7 2 9 " > < t r > < t d w i d t h = " 7 2 9 " > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " > < ! - - g o o g l e _ a d _ c l i e n t = " p u b - 1 9 5 1 4 3 8 3 5 9 2 9 1 1 3 2 " ; g o o g l e _ a l t e r n a t e _ c o l o r = " F F F F F F " ; g o o g l e _ a d _ w i d t h = 7 2 8 ; g o o g l e _ a d _ h e i g h t = 9 0 ; g o o g l e _ a d _ f o r m a t = " 7 2 8 x 9 0 _ a s " ; g o o g l e _ a d _ c h a n n e l = " " ; g o o g l e _ c o l o r _ b o r d e r = " B 4 D 0 D C " ; g o o g l e _ c o l o r _ b g = " E C F 8 F F " ; g o o g l e _ c o l o r _ l i n k = " 0 0 0 0 C C " ; g o o g l e _ c o l o r _ u r l = " 0 0 8 0 0 0 " ; g o o g l e _ c o l o r _ t e x t = " 6 F 6 F 6 F " ; / / - - > < / s c r i p t > < s c r i p t t y p e = " t e x t / j a v a s c r i p t " s r c = " h t t p : / / p a g e a d 2 . g o o g l e s y n d i c a t i o n . c o m / p a g e a d / s h o w _ a d s . j s " > < / s c r i p t > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 2 0 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < p a l i g n = " c e n t e r " > < i m g b o r d e r = " 0 " s r c = " . . / n o v a b a n n e r . g i f " w i d t h = " 5 6 9 " h e i g h t = " 9 8 " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < / p > < d i v a l i g n = " c e n t e r " > < c e n t e r > < t a b l e b o r d e r = " 0 " c e l l p a d d i n g = " 0 " c e l l s p a c i n g = " 0 " w i d t h = " 1 0 0 % " > < t r > < t d w i d t h = " 2 0 % " > < / t d > < t d w i d t h = " 6 0 % " > < p a l i g n = " r i g h t " > < f o n t f a c e = " V e r d a n a " s i z e = " 1 " > A D V E R T I S E M E N T < / f o n t > < / t d > < t d w i d t h = " 2 0 % " > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " > < / t d > < / t r > < t r > < t d w i d t h = " 1 0 0 % " h e i g h t = " 1 0 " > < / t d > < / t r > < / t a b l e > < / c e n t e r > < / d i v > < / t d > < / t r > < / t a b l e > < / b o d y > < / h t m l >