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Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety | Abdel-Monem | European Journal of Chemistry

Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety

Wafaa Ramzy Abdel-Monem

Abstract


7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.

1_3_168_172_800


Keyword(s)


1,2,4-Triazine; 1,2,4-Triazole; Imidazole; Polyheterocyclic nitrogen systems; Antimicrobial activity

European Journal of Chemistry, 1 (3), (2010), 168-172

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DOI: http://dx.doi.org/10.5155/eurjchem.1.3.168-172.29

 

Cited-By

[1]. Synthesis and Antimicrobial Activities of Some 6-Methyl-3-Thioxo-2,3-Dihydro-1,2,4-Triazine Derivatives
Ahmed A. El-Barbary, Ashraf A. El-Shehawy, Nabiha I. Abdo
Phosphorus, Sulfur, and Silicon and the Related Elements  Volume: 189  Issue: 3  First page: 400  Year: 2014  
/

[2]. Voltammetric behavior, biocidal effect and synthesis of some new nanomeric fused cyclic thiosemicarbazones and their mercuric(II) salts
M.S.T. Makki, R.M. Abdel-Rahman, M.S. El-Shahawi
Arabian Journal of Chemistry  Year: 2011  
/

 


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