This study is aimed at finding out the molluscicidal activities of Sasanqua Saponin extracted from the residue of camellia oleasa (tea-cake seeds). The sasanqua saponin was obtained from Chenxi Chemical plant, Peoples’ Republic of China. The molluscicidal activities were tested in the laboratory and against the eggs, juvenile and adult snails of Oncomelania hupensis and the intermediate host of schistosoma japonicum (intestinal schistosomiasis). The immersion technique was adopted in the experiments. Sasanqua saponin extracted from the residue of Camellia oleasa (tea-cake seeds) was provided by Chenxi Chemical Plant, Peoples’ Republic of China. The mollusciciding activities of the sasanqua saponin against eggs. Juvenile and adult Oncomelania hupensis snails (intermediate host of Schistosoma japonicum) were carried out in the laboratory and the field using immersion technique. The mortality rate of adult snails exposed to 10 ppm of sasanqua saponin at 20°C for 48 h was 96% and Lc90 were 2.76 and 10.34 ppm respectively. At 5 ppm exposure concentration for 48 and 72 h, the mortality rate was 96 and 100%, respectively. Lc50 and Lc90 after 48 h were 1.31 and 3.10 pm, respectively. The hatching rate snail eggs immersed in 5 ppm of sasanqua saponin after 72 h were 14%. There was on hatching of eggs at 10 ppm of sasanque saponin while the blank or control had 78% hatching rate. The mortality rates for juvenile snails exposed to 10 ppm of sasanqua saponin were 93.3 and 100% respectively after 48 and 72 h of incubation. Toxicity test showed that sasanqua saponin do not have any adverse effects on silver carp.