Influence of myocardial infarction on changes in the expression of angiotensin type 1 receptor in the rat prostate
Agnieszka W. Piastowska-Ciesielska, Jacek Drobnik, Joanna Zarzyńska, Kamila Domińska, John A. Russell, Tomasz OchędalskiFull Text:
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Angiotensin II (AngII) is the biologically active peptide of the renin-angiotensin system (RAS). Tissue-
based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental
and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of
the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression
of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI
are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown.
In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein
and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left
coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were
measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression
after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin
receptor type AT1 in the prostate at the protein and mRNA level. ( Folia Histochemica et Cytobiologica
2011, Vol. 49, No. 3, 497–503)
based, local RAS has been identified in the prostate, testis, epididymis and coagulating glands. Experimental
and clinical studies have consistently shown that myocardial infarction (MI) is associated with activation of
the systemic RAS with increased concentration of angiotensin peptides in the blood and changes in expression
of angiotensin receptors (AT). Changes in angiotensin receptors in the renal and cardiovascular system after MI
are well recognized, but the effects of MI influence on changes in other tissue like the prostate gland are unknown.
In the present study, we investigated the effect of myocardial infarction on angiotensin receptor protein
and mRNA expression in the rat prostate gland. MI model was established in Wistar rats by ligating the left
coronary artery (modified Selye method). The levels of AT1a-b and AT2 receptor mRNAs and proteins were
measured in the rat prostate. Our study demonstrates tissue-specific changes in AT1a-b and AT2 receptor expression
after myocardial infarction. The results show that MI has a strong influence on the expression of angiotensin
receptor type AT1 in the prostate at the protein and mRNA level. ( Folia Histochemica et Cytobiologica
2011, Vol. 49, No. 3, 497–503)
Keywords
angiotensin receptor; myocardial infarction; prostate; rat
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