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Standardization of extract of Leucaena leucocephala (lmk) De Wit seeds by α-glucosidase inhibitor | A | International Journal of Phytomedicine

Standardization of extract of Leucaena leucocephala (lmk) De Wit seeds by α-glucosidase inhibitor

Syamsudin A

Abstract


Extracts of Leucaena leucocephala (lmk) De Wit seeds were collected from different areas in Java; they include Jakarta, Cengkareng, Bogor and Bandung. Each extract was examined for water content, ash content, acid-insoluble ash content, and α- glycosidase inhibition assay. The results showed that ethanolic extracts of Leucaena leucocephala (lmk) De Wit seeds collected from Bandung were found to be most active in inhibiting the formation of α-glycosidase compounds with an IC50 value of 7,46 ± 0,21 μg/ml, which was confirmed with ash content of 5,58 ± 0,04, acid-insoluble ash content of 0,55 ± 1,33, and water content of 26,22 ± 0,90.

Keywords: extracts of (Leucaena leucocephala (lmk) De Wit), α-glucosidase inhibition activity, different areas in Java.


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