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Vascular Health and Risk Management
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Update on the everolimus-eluting coronary stent system: results and implications from the SPIRIT clinical trial program
Review
(5883) Total Article Views
Authors:
R Michael Kirchner, J Dawn Abbott
Published Date December 2009 Volume 2009:5 Pages 1089 - 1097
DOI: http://dx.doi.org/10.2147/VHRM.S5618
R Michael Kirchner, J Dawn Abbott
Department of Cardiology, Rhode Island Hospital, Brown Medical School, Providence, RI, USA
Abstract: Drug-eluting stents (DES) have had a major impact in interventional cardiology. Compared to bare metal stents, they significantly reduce restenosis and the need for target vessel revascularization. Four DES are available in the US, the first-generation sirolimuseluting (Cypher®) and paclitaxel-eluting (Taxus®) stents and later approved second-generation everolimus-eluting (Xience V®) and zotarolimus-eluting (Endeavor®) stents. The Xience V stent was approved on the basis of clinical efficacy and safety data from 3 studies in the SPIRIT clinical trial program. Within this trial series, the Xience V was superior to its bare metal stent counterpart, the Vision® stent, and noninferior to the paclitaxel-eluting stent for target vessel failure at 9 months. This review provides a comprehensive assessment of the data derived from both the pre- and post-approval randomized controlled trials and registry studies of Xience V that comprise the SPIRIT clinical trial program including recently published mid-term outcomes. The implications of the results in terms of interventional practice will be discussed.
Keywords: cobalt-chromium, drug-eluting stent, everolimus, percutaneous coronary intervention, Xience V
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