ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE
Abstract
The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile  MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor  activity in EAC-bearing mice.
Keywords
DOI: 10.7439/ijbr.v2i4.103
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © 2008 - 2010 Scholar Science Journals All rights reserved.
120, Swagat Nagar, NGP, INDIA